产品说明书
Acarbose
 |
同义名 : | 阿卡波糖水合物 ;BAY g 5421 |
| CAS号 : | 56180-94-0 | |
| 货号 : | A357603 | |
| 分子式 : | C25H43NO18 | |
| 纯度 : | 98% | |
| 分子量 : | 645.605 | |
| MDL号 : | MFCD00869592 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
H2O: 100 mg/mL(154.89 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | α-glucosidases are enzymes responsible for the metabolism of complex carbohydrates into absorbable monosaccharide units. However, hyperglycemia causes a number of abnormalities which contribute to the development of long-term complications of diabetes. Acarbose, an anti-diabetic drug, is an intestinal α-glucosidase inhibitor[3]. In TNF-α pre-treated A7r5 cells, acarbose (1, 2, and 3 μM) dose-dependently decreased β-galactosidase, Ras expression and increased p-AMPK expression. In HCD (high cholesterol diet)-fed rabbits, the numbers of atherosclerotic plaques in the aortic arch were significantly decreased by acarbose treatment (2.5 and 5.0 mg/kg per day). Further, acarbose (2.5 and 5.0 mg/kg) significantly and dose-dependently decreased the intensity of neointimal IL-6, TNF-α, and iNOS staining, and significantly increased the intensity of neointimal p-AMPK staining. Moreover, acarbose (2.5 and 5.0 mg/kg) significantly and dose-dependently decreased neointimal Ras and β-galactosidase expression in HCD-fed rabbits[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02476760 | - | Completed | - | Canada, Quebec ... 展开 >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 收起 << | |
| NCT02475499 | - | Completed | - | Canada, Quebec ... 展开 >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 收起 << | |
| NCT00000620 | Atherosclerosis ... 展开 >> Cardiovascular Diseases Hypercholesterolemia Hypertension Diabetes Mellitus, Type 2 Diabetes Mellitus Coronary Disease 收起 << | Phase 3 | Completed | - | United States, Minnesota ... 展开 >> Minneapolis Medical Research Foundation Minneapolis, Minnesota, United States, 55404 United States, New York Columbia University New York, New York, United States, 10027 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27106 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Tennessee Veterans Affairs Memphis, Tennessee, United States, 38104 United States, Washington University of Washington Seattle, Washington, United States, 98195 Canada, Ontario McMaster University Hamilton, Ontario, Canada 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.55mL 0.31mL 0.15mL |
7.74mL 1.55mL 0.77mL |
15.49mL 3.10mL 1.55mL |
| 参考文献 |
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