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ALK inhibitor 2 {[allProObj[0].p_purity_real_show]}

货号:A524942

ALK inhibitor 2 is a selective inhibitor for the ALK kinase.

ALK inhibitor 2 化学结构 CAS号:761438-38-4
ALK inhibitor 2 化学结构
CAS号:761438-38-4
ALK inhibitor 2 3D分子结构
CAS号:761438-38-4
ALK inhibitor 2 化学结构 CAS号:761438-38-4
ALK inhibitor 2 3D分子结构 CAS号:761438-38-4
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ALK inhibitor 2 纯度/质量文件 产品仅供科研

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产品名称 ALK 其他靶点 纯度
ASP3026 +

ALK, IC50: 3.5 nM

99%+
ALK-IN-1 ++++

ALK, IC50: 0.07 nM

98+%
Crizotinib ++++

ALK, IC50: 24 nM

ROS1, Ki: <0.025 nM

98%
Entrectinib 99%+
Brigatinib +++

ROS1, IC50: 1.9 nM

ALK, IC50: 0.37 nM

FLT3 98%
NVP-TAE 684 +

ALK, IC50: 3 nM

99%+
Alectinib ++

ALK (F1174L), IC50: 3.5 nM

ALK, IC50: 1.9 nM

98%
Ceritinib +++

ALK, IC50: 0.2 nM

IGF-1R,Insulin Receptor 98%
GSK1838705A +++

ALK, IC50: 0.5 nM

IGF-1R,Insulin Receptor 99%
AZD-3463 ++

ALK, Ki: 0.75 nM

IGF-1R 99%
Lorlatinib ++++

ALK (L1196M), Ki: 0.07 nM

ROS1, Ki: <0.07 nM

98%
Repotrectinib +

ALK(G1202R), IC50: 1.26 nM

ALK(L1196M), IC50: 1.01 nM

Src 99%
Belizatinib ++

ALK, IC50: 0.7 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

ALK inhibitor 2 生物活性

描述 Anaplastic lymphoma kinase (ALK) encodes a highly conserved receptor tyrosine kinase (RTK) within the insulin receptor superfamily, comprised of an extracellular domain, a single-pass transmembrane region, and an intracellular kinase domain[2]. ALK inhibitors are potential anti-cancer drugs that act on tumours with variations of ALK such as an EML4-ALK[3]. ALK inhibitor 2 is a chemical analogue of LDK378 that is a potent ALK inhibitor[4].

ALK inhibitor 2 参考文献

[1]US20130096100

[2]Lin JJ, Riely GJ, Shaw AT. Targeting ALK: Precision Medicine Takes on Drug Resistance. Cancer Discov. 2017 Feb;7(2):137-155. doi: 10.1158/2159-8290.CD-16-1123. Epub 2017 Jan 25. PMID: 28122866; PMCID: PMC5296241.

[3]Palmer RH, Vernersson E, Grabbe C, Hallberg B. Anaplastic lymphoma kinase: signalling in development and disease. Biochem J. 2009 May 27;420(3):345-61. doi: 10.1042/BJ20090387. PMID: 19459784; PMCID: PMC2708929.

[4]Marsilje TH, Pei W, Chen B, Lu W, Uno T, Jin Y, Jiang T, Kim S, Li N, Warmuth M, Sarkisova Y, Sun F, Steffy A, Pferdekamper AC, Li AG, Joseph SB, Kim Y, Liu B, Tuntland T, Cui X, Gray NS, Steensma R, Wan Y, Jiang J, Chopiuk G, Li J, Gordon WP, Richmond W, Johnson K, Chang J, Groessl T, He YQ, Phimister A, Aycinena A, Lee CC, Bursulaya B, Karanewsky DS, Seidel HM, Harris JL, Michellys PY. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. J Med Chem. 2013 Jul 25;56(14):5675-90. doi: 10.1021/jm400402q. Epub 2013 Jun 26. PMID: 23742252.

ALK inhibitor 2 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.93mL

0.39mL

0.19mL

9.65mL

1.93mL

0.97mL

19.30mL

3.86mL

1.93mL

ALK inhibitor 2 技术信息

CAS号761438-38-4
分子式C23H28ClN7O3S
分子量 518.032
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,2-8°C

溶解度

DMSO: 50 mg/mL(96.52 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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