AEBSF HCl is a irreversible inhibitor of proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
HazMat Fee +
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
AEBSF directly inhibits β-secretase, thereby suppressing the constant production of Aβ across five diverse human cell lines, including both neural and non-neural types[1]. As a serine protease inhibitor, AEBSF prevents the lysis of leukemic cells by human macrophages without affecting the macrophage release of TNF-α and IL-1β[2]. AEBSF disrupts blastocyst development on endometrial cells and impedes the adhesion of HeLa cells to HUVECs by modifying the pattern of protein secretion[4].
体内研究
AEBSF administration (76.8 mg/kg daily, i.p.) extends the survival time of mice infected with a lethal T. gondii [3].
AEBSF also mitigates airway responsiveness and associated inflammation in a mouse model induced by cockroach allergens[4].
体外研究
AEBSF directly inhibits β-secretase, thereby suppressing the constant production of Aβ across five diverse human cell lines, including both neural and non-neural types[1].
As a serine protease inhibitor, AEBSF prevents the lysis of leukemic cells by human macrophages without affecting the macrophage release of TNF-α and IL-1β[2].
AEBSF disrupts blastocyst development on endometrial cells and impedes the adhesion of HeLa cells to HUVECs by modifying the pattern of protein secretion[4].
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