货号:A178436 同义名: MCI-9038;MD-805
Argatroban is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant.
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产品名称 | Thrombin ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
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Dabigatran |
+++
Thrombin, IC50: 9.3 nM |
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Dabigatran etexilate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Argatroban | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||||
Heparin sodium salt | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
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描述 | Argatroban (MD-805), targeting thrombin specifically, offers a beneficial approach to thrombus prevention without increasing the risk of bleeding. It is administered at a rate of 0.5 to 2 micrograms/kg/min as a safe anticoagulant during left heart bypass procedures for traumatic aortic ruptures accompanied by multiple organ injuries[1]. Comparatively, Argatroban (MD-805) enhances the effectiveness of reperfusion treatments with TPA in patients with acute myocardial infarction (AMI), especially those with delayed presentations. Clinical trials indicate that both major bleeding incidents and adverse clinical outcomes are less frequent in patients treated with Argatroban than those receiving heparin[2]. |
体外研究 | Argatroban (MD-805), targeting thrombin specifically, offers a beneficial approach to thrombus prevention without increasing the risk of bleeding. It is administered at a rate of 0.5 to 2 micrograms/kg/min as a safe anticoagulant during left heart bypass procedures for traumatic aortic ruptures accompanied by multiple organ injuries[1]. Comparatively, Argatroban (MD-805) enhances the effectiveness of reperfusion treatments with TPA in patients with acute myocardial infarction (AMI), especially those with delayed presentations. Clinical trials indicate that both major bleeding incidents and adverse clinical outcomes are less frequent in patients treated with Argatroban than those receiving heparin[2]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00603824 | Heparin-Induced Thrombocytopen... 展开 >>ia 收起 << | Phase 4 | Withdrawn(PI relocated) | - | - |
NCT01911624 | Staphylococcus Aureus Bacterae... 展开 >>mia 收起 << | Phase 2 | Completed | - | Belgium ... 展开 >> KUleuven/UZ Gasthuisberg Leuven, Belgium, 3000 收起 << |
NCT00921856 | Coronary Vasospasm ... 展开 >> Microvascular Angina Coronary Artery Disease 收起 << | Not Applicable | Recruiting | December 2019 | Germany ... 展开 >> Robert Bosch Medical Center Recruiting Stuttgart, Germany, 70376 Contact: Peter Ong, MD +4971181016048 petereong@gmail.com Contact: Anastasios Athanasiadis, MD +4971181015444 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.97mL 0.39mL 0.20mL |
9.83mL 1.97mL 0.98mL |
19.66mL 3.93mL 1.97mL |
CAS号 | 74863-84-6 |
分子式 | C23H36N6O5S |
分子量 | 508.634 |
别名 | MCI-9038;MD-805;Argipidine |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(206.44 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |