Argatroban (MD-805), targeting thrombin specifically, offers a beneficial approach to thrombus prevention without increasing the risk of bleeding. It is administered at a rate of 0.5 to 2 micrograms/kg/min as a safe anticoagulant during left heart bypass procedures for traumatic aortic ruptures accompanied by multiple organ injuries[1]. Comparatively, Argatroban (MD-805) enhances the effectiveness of reperfusion treatments with TPA in patients with acute myocardial infarction (AMI), especially those with delayed presentations. Clinical trials indicate that both major bleeding incidents and adverse clinical outcomes are less frequent in patients treated with Argatroban than those receiving heparin[2].
体外研究
Argatroban (MD-805), targeting thrombin specifically, offers a beneficial approach to thrombus prevention without increasing the risk of bleeding. It is administered at a rate of 0.5 to 2 micrograms/kg/min as a safe anticoagulant during left heart bypass procedures for traumatic aortic ruptures accompanied by multiple organ injuries[1].
Comparatively, Argatroban (MD-805) enhances the effectiveness of reperfusion treatments with TPA in patients with acute myocardial infarction (AMI), especially those with delayed presentations. Clinical trials indicate that both major bleeding incidents and adverse clinical outcomes are less frequent in patients treated with Argatroban than those receiving heparin[2].
United Kingdom
... 展开 >> Department of Cardiology, St George's Healthcare NHS Trust
Recruiting
London, England, United Kingdom, SW17 0RE
Contact: Peter E Ong, MD +44208725 ext 2628 pong@sgul.ac.uk
Sub-Investigator: Peter E Ong, MD 收起 <<
United States, Ohio
... 展开 >>
University of Cincinnati Medical Center
Not yet recruiting
Cincinnati, Ohio, United States, 45267
Contact: Natalie Kreitzer, MD kreitzne@UCMAIL.UC.EDU 收起 <<
United States, Illinois
... 展开 >>
University of Chicago, Section of Nephrology
Chicago, Illinois, United States, 60637
United States, Minnesota
DaVita Clinical Research
Minneapolis, Minnesota, United States, 55404 收起 <<
United States, California
... 展开 >>
Mattel Children's Hospital at UCLA
Los Angeles, California, United States, 90095
Children's Hospital of Orange County
Orange, California, United States, 92868
United States, Illinois
Rush University Medical Center
Chicago, Illinois, United States, 60612
University of Chicago Children's Hospital
Chicago, Illinois, United States, 60637
Children's Hospital of Illinois
Peoria, Illinois, United States, 61614
United States, Kentucky
Kosair Children's Hospital, University of Louisville
Louisville, Kentucky, United States, 40202
United States, Massachusetts
Children's Hospital of Boston
Boston, Massachusetts, United States, 02115
United States, Michigan
Michigan Congenital Heart Center
Ann Arbor, Michigan, United States, 48109
United States, Ohio
Rainbow Babies at Children's Hospital
Cleveland, Ohio, United States, 44106
United States, Oregon
Oregon Health & Science University
Portland, Oregon, United States, 97201
United States, Pennsylvania
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
United States, Utah
Primary Children's Medical Center
Salt Lake City, Utah, United States, 84113
United States, Washington
Children's Hospital and Regional Medical Center
Seattle, Washington, United States, 98105 收起 <<
Japan
... 展开 >> National Hospital Organization Nagoya Medical Center
Nagoya, Aichi, Japan, 4600001
Nagoya University Hospital
Nagoya, Aichi, Japan, 4668560
Nagoya Daini Red Cross Hospital
Nagoya, Aichi, Japan, 4668650
National Hospital Organization Hakodate National Hospital
Hakodate, Hokkaido, Japan, 0418512
National Hospital Organization Hokkaido Cancer Center
Sapporo, Hokkaido, Japan, 0030804
Kurume University Hospital
Kurume, Hukuoka, Japan, 8300011
Kobe University Hospital
Kobe, Hyogo, Japan, 6500017
Kobe City General Hospital
Kobe, Hyogo, Japan, 6500046
Iwate Medical University Hospital
Morioka, Iwate, Japan, 0208505
Tokai University Hospital
Isehara, Kanagawa, Japan, 2591193
Mie University Hospital
Tsu, Mie, Japan, 5148507
National Cardiovascular Center
Suita, Osaka, Japan, 5658565
Sakakibara Memorial Hospital
Fuchu, Tokyo, Japan, 1830003
National Hospital Organization Iwakuni Clinical Center
Iwakuni, Yamaguchi, Japan, 7408510
Yamaguchi University Hospital
Ube, Yamaguchi, Japan, 7558505
Kyoto Second Red Cross Hospital
Kyoto, Japan, 6028026
Kyoto University Hospital
Kyoto, Japan, 6068507
The University of Tokyo Hospital
Tokyo, Japan, 1138655
National Hospital Organization Tokyo Medical Center
Tokyo, Japan, 1528902
Keio University Hospital
Tokyo, Japan, 1608582 收起 <<
United States, Alabama
... 展开 >>
University of Alabama-Birmingham
Birmingham, Alabama, United States, 35249
United States, California
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
United States, Louisiana
Tulane University
New Orleans, Louisiana, United States, 70112
United States, Texas
University of Texas-Southwestern Dallas
Dallas, Texas, United States, 75390
Memorial Hermann Hospital-Medical Center
Houston, Texas, United States, 77030
Memorial Hermann Southwest Hospital
Houston, Texas, United States, 77074 收起 <<
Terminated(The study was halte... 展开 >>d prematurely at 90 of 105 planned patients due to the beneficial results of embolectomy clinical trials.) 收起 <<
China, Liaoning
... 展开 >>
General Hospital of Shenyang Military Region
Recruiting
Shenyang, Liaoning, China, 10016
Contact: Hui-sheng Chen, Doctor 收起 <<
Terminated(The study was halte... 展开 >>d prematurely at 90 of 105 planned patients due to the beneficial results of embolectomy clinical trials.) 收起 <<
-
United States, Texas
... 展开 >>
University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030 收起 <<
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