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肝素钠 (MW 15kDa) /Heparin sodium salt {[allProObj[0].p_purity_real_show]}

货号:A170554 同义名: 肝素钠 / Sodium heparin;Sodium heparinate

Heparin sodium salt (Sodium heparin) 是一种抗凝剂,可与抗凝血酶III (ATIII) 可逆地结合,大大加快了ATIII使凝血酶因子IIa和Xa失活的速度。Heparin sodium salt 显著抑制外泌体与细胞的相互作用。

Heparin sodium salt 化学结构 CAS号:9041-08-1
Heparin sodium salt 化学结构
CAS号:9041-08-1
Heparin sodium salt 3D分子结构
CAS号:9041-08-1
Heparin sodium salt 化学结构 CAS号:9041-08-1
Heparin sodium salt 3D分子结构 CAS号:9041-08-1
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Heparin sodium salt 纯度/质量文件 产品仅供科研

货号:A170554 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Thrombin 其他靶点 纯度
Dabigatran +++

Thrombin, IC50: 9.3 nM

98%
Dabigatran etexilate 98%
Argatroban 99%+
Heparin sodium salt ≥150 u/mg
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Heparin sodium salt 生物活性

靶点
  • Thrombin

描述 Heparin sodium is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa. Heparin sodium salt significantly inhibits exosome-cell interactions. Heparin is principally located in the granules of tissue mast cells that are closely associated with the immune response. Heparin makes numerous contacts with both FGF-2 and FGFR-1 stabilizing FGF–FGFR binding. Heparin also makes contacts with the FGFR-1 of the adjacent FGF–FGFR complex, thus seeming to promote FGFR dimerization[1]. Heparan sulfate plays a dual role in exosome-cell interaction; heparan sulfate on exosomes captures fibronectin, and on target cells it acts as a receptor for fibronectin. Removal of heparan sulfate from the exosome surface releases fibronectin and dramatically inhibits exosome-target cell interaction. Therapeutic disruption of fibronectin-heparan sulfate interactions will negatively impact myeloma tumor growth and progression[2]. Heparin can affect the proliferation, adhesion, angiogenesis, migration and invasion of cancer cells via multiple mechanisms. The main mechanisms involve inhibition of heparanase, P-/L-selectin, angiogenesis, and interference with the CXCL12-CXCR4 axis[3].

Heparin sodium salt 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02533011 - Completed - United States, Delaware ... 展开 >> Christiana Care Health System Newark, Delaware, United States, 19718 收起 <<
NCT02477072 Peripheral Revascularisation Not Applicable Completed - Canada, Quebec ... 展开 >> Centre Hospitalier de l'Université de Montréal (CHUM-Hôtel-Dieu) Montreal, Quebec, Canada, H2W 1T8 收起 <<
NCT01044888 Off Pump Coronary Artery Bypas... 展开 >>s Surgery 收起 << Not Applicable Completed - Korea, Republic of ... 展开 >> Yonsei University Severance hospital Seoul, Seodaemungu, Korea, Republic of 收起 <<

Heparin sodium salt 参考文献

[1]Capila I, Linhardt RJ. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412

[2]Purushothaman A, Bandari SK, Liu J, Mobley JA, Brown EE, Sanderson RD. Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions. J Biol Chem. 2016 Jan 22;291(4):1652-1663

[3]Ma SN, Mao ZX, Wu Y, Liang MX, Wang DD, Chen X, Chang PA, Zhang W, Tang JH. The anti-cancer properties of heparin and its derivatives: a review and prospect. Cell Adh Migr. 2020 Dec;14(1):118-128

Heparin sodium salt 技术信息

CAS号9041-08-1
分子式
分子量
别名 肝素钠 ;Sodium heparin;Sodium heparinate;Heparin sodium
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

H2O: 20 mg/mL,配合低频超声助溶

动物实验配方
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