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ABMA {[allProObj[0].p_purity_real_show]}

货号:A1365139 Ambeed 开学季,买赠积分,赢豪礼

ABMA是一种广谱细胞内毒素和病原体的抑制剂,能有效保护宿主细胞免受多种病原体(包括病毒、细胞内细菌寄生虫)的侵害。ABMA 主要选择性作用于宿主细胞的晚期内体,而非直接针对毒素或病原体本身,展现出强大的广谱抗感染潜力。

ABMA 化学结构 CAS号:332108-65-3
ABMA 化学结构
CAS号:332108-65-3
ABMA 3D分子结构
CAS号:332108-65-3
ABMA 化学结构 CAS号:332108-65-3
ABMA 3D分子结构 CAS号:332108-65-3
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ABMA 纯度/质量文件 产品仅供科研

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ABMA 生物活性

描述 ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. It effectively shields cells from diverse toxins and pathogens, such as viruses, intracellular bacteria, and parasites. ABMA selectively acts within host cell late endosomes, rather than directly targeting the toxin or pathogen itself. It possesses broad-spectrum anti-infection activity [1][2].
体内研究

ABMA (2-200 mg/kg; intraperitoneal injection; female BALB/c mice) administration shields mice against nasal instillation of an LD90 of ricin [1].

体外研究

ABMA defends cells against four bacterial toxins (Corynebacterium diphtheriae (DT; EC50 of 62.9 μM), Bacillus anthracis (LT), Clostridium difficile toxin B (TcdB; EC50 of 73.3 μM), Clostridium sordellii lethal toxin (TcsL; EC50 of 86.7 μM)), three viruses (Ebola (EC50 of 3.3 μM), rabies (EC50 of 19.4 μM), dengue-4 virus (EC50 of 8.2 μM)), two species of Chlamydiales intracellular bacteria, and the parasite Leishmania infantum (EC50 of 7.1 μM) at the micromolar level [1].

In A549 cells, ABMA treatment reduces ricin cytotoxicity with an EC50 of 3.8 μM, and exhibits a protection factor (R) at 30 μM ranging from 5 to 10. ABMA maintains nearly 100% of its biological activity against ricin-induced cytotoxicity for up to six days [1].

ABMA 参考文献

[1]Wu Y, et al. ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments.

[2]Wu Y, et al. DABMA: A Derivative of ABMA with Improved Broad-Spectrum Inhibitory Activity of Toxins and Viruses. ACS Med Chem Lett. 2019 Jul 2;10(8):1140-1147.

ABMA 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.85mL

0.57mL

0.29mL

14.27mL

2.85mL

1.43mL

28.55mL

5.71mL

2.85mL

ABMA 技术信息

CAS号332108-65-3
分子式C18H24BrNO
分子量 350.293
别名
运输蓝冰
存储条件

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 120 mg/mL(342.57 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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