7-Hydroxyflavone is a flavonoid isolated from M. indica, with anti-inflammatory activity. 7-Hydroxyflavone protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway .
7-hydroxflavone can protect renal cells from nicotine induced cytotoxicity through ERK/Nrf2/HO-1 pathway[2]. 7-Hydroxflavone could quench the intrinsic fluorescence of HEWL (hen egg white lysozyme) through static quenching mechanism while the binding affinity of 7HF (7-Hydroxyflavone) was found to be greater than 3HF under experimental conditions. The binding constant (Kb) values were estimated to be in the order of 104 M-1 and decreased with the rise in temperature. The flavonoid was found to inhibit the enzymatic activity of HEWL[4]. In addition, 7-Hydroxyflavone and its phosphate ester (FIP) were predicted to bind with EV71 (Enterovirus 71) 3Cpro. In an in vitro protease inhibition assay, FIP inhibited EV71 3Cpro protease activity. It was highly active against EV71, protecting cells from EV71 infection. Replication of viral RNA and formation of EV71 plaque were all strongly inhibited in cells[5].
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