产品说明书

7-Hydroxyflavone

Print
Chemical Structure| 6665-86-7 同义名 : NSC 94258;7-hydroxy-2-Phenylchromone
CAS号 : 6665-86-7
货号 : A798911
分子式 : C15H10O3
纯度 : 98%
分子量 : 238.238
MDL号 : MFCD00006835
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(503.7 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 7-hydroxflavone can protect renal cells from nicotine induced cytotoxicity through ERK/Nrf2/HO-1 pathway[2]. 7-Hydroxflavone could quench the intrinsic fluorescence of HEWL (hen egg white lysozyme) through static quenching mechanism while the binding affinity of 7HF (7-Hydroxyflavone) was found to be greater than 3HF under experimental conditions. The binding constant (Kb) values were estimated to be in the order of 104 M-1 and decreased with the rise in temperature. The flavonoid was found to inhibit the enzymatic activity of HEWL[4]. In addition, 7-Hydroxyflavone and its phosphate ester (FIP) were predicted to bind with EV71 (Enterovirus 71) 3Cpro. In an in vitro protease inhibition assay, FIP inhibited EV71 3Cpro protease activity. It was highly active against EV71, protecting cells from EV71 infection. Replication of viral RNA and formation of EV71 plaque were all strongly inhibited in cells[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.20mL

0.84mL

0.42mL

20.99mL

4.20mL

2.10mL

41.97mL

8.39mL

4.20mL
参考文献

[1]Vinutha K, et al. Aqueous extract from Madhuca indica bark protects cells from oxidative stress caused by electron beam radiation: in vitro, in vivo and in silico approach. Heliyon. 2019 May 30;5(5):e01749.

[2]Sengupta B, Sahihi M, Dehkhodaei M, Kelly D, Arany I. Differential roles of 3-Hydroxyflavone and 7-Hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cells. PLoS One. 2017;12(6):e0179777. Published 2017 Jun 22

[3]Sengupta B, et al. Differential roles of 3-Hydroxyflavone and 7-Hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cells. PLoS One. 2017 Jun 22;12(6):e0179777.

[4]Das S, Rohman MA, Singha Roy A. Exploring the non-covalent binding behaviours of 7-hydroxyflavone and 3-hydroxyflavone with hen egg white lysozyme: Multi-spectroscopic and molecular docking perspectives. J Photochem Photobiol B. 2018;180:25‐38

[5]Wang J, Su H, Zhang T, et al. Inhibition of Enterovirus 71 replication by 7-hydroxyflavone and diisopropyl-flavon7-yl Phosphate. PLoS One. 2014;9(3):e92565. Published 2014 Mar 24