3-O-Acetyloleanolic Acid exhibits anti-angiogenic effects and induces apoptosis in HUVECs and HCT-116 cells, it is a natural product isolated and purified from the herbs of Phytolacca americana.
3-O-acetyloleanolic acid (3AOA), a pentacyclic triterpenoid compound isolated from seeds of Vigna sinensis K., has been reported to have potent anti-angiogenesis and anti-tumor activities. 3AOA inhibits VEGF-A-induced lymphangiogenesis and sentinel lymph node metastasis both in vitro and in vivo[3]. 3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. 3-O-acetyloleanolic acid induces apoptosis in HCT-116 cells mediated by an extrinsic apoptosis signaling cascade via up-regulation of DR5[4]. 3-O-acetyloleanolic acid exerts an apoptosis in cancer cell lines, is an inhibition of both atopic and allergic contact dermatitis in murine model, and a suppression of inflammatory bone loss in mice[5]. 3AOA has an inhibitory effect on angiogenesis and lymphangiogenesis induced by angiopoietin-1 both in vitro and in vivo, and the inhibitory effect of 3AOA is probably due to suppression of angiopoietin-1/Tie-2 signaling in HUVEC (human umbilical vein endothelial cells) and HLMEC (human lymphatic microvascular endothelial cells) [6].
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