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3-O-Acetyloleanolic acid

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Chemical Structure| 4339-72-4 同义名 : 3-​O-​Acetyloleanolic acid;Oleanolic Acid Acetate;3-Acetyloleanolic Acid
CAS号 : 4339-72-4
货号 : A269919
分子式 : C32H50O4
纯度 : 98%
分子量 : 498.737
MDL号 : MFCD09752429
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 2 mg/mL(4.01 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 3-O-acetyloleanolic acid (3AOA), a pentacyclic triterpenoid compound isolated from seeds of Vigna sinensis K., has been reported to have potent anti-angiogenesis and anti-tumor activities. 3AOA inhibits VEGF-A-induced lymphangiogenesis and sentinel lymph node metastasis both in vitro and in vivo[3]. 3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. 3-O-acetyloleanolic acid induces apoptosis in HCT-116 cells mediated by an extrinsic apoptosis signaling cascade via up-regulation of DR5[4]. 3-O-acetyloleanolic acid exerts an apoptosis in cancer cell lines, is an inhibition of both atopic and allergic contact dermatitis in murine model, and a suppression of inflammatory bone loss in mice[5]. 3AOA has an inhibitory effect on angiogenesis and lymphangiogenesis induced by angiopoietin-1 both in vitro and in vivo, and the inhibitory effect of 3AOA is probably due to suppression of angiopoietin-1/Tie-2 signaling in HUVEC (human umbilical vein endothelial cells) and HLMEC (human lymphatic microvascular endothelial cells) [6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.01mL

0.40mL

0.20mL

10.03mL

2.01mL

1.00mL

20.05mL

4.01mL

2.01mL
参考文献

[1]Cui EJ, Hwang-Bo J, et al. 3-O-Acetyloleanolic acid exhibits anti-angiogenic effects and induces apoptosis in human umbilical vein endothelial cells. Biotechnol Lett. 2013 Nov;35(11):1807-15.

[2]Yoo KH, Park JH, et al. 3-O-acetyloleanolic acid induces apoptosis in human colon carcinoma HCT-116 cells. Phytother Res. 2012 Oct;26(10):1541-6.

[3]Hwang-Bo J, Bae MG, Park JH, Chung IS. 3-O-Acetyloleanolic acid inhibits VEGF-A-induced lymphangiogenesis and lymph node metastasis in an oral cancer sentinel lymph node animal model. BMC Cancer. 2018;18(1):714. Published 2018 Jul 5

[4]Yoo KH, Park JH, Cui EJ, et al. 3-O-acetyloleanolic acid induces apoptosis in human colon carcinoma HCT-116 cells. Phytother Res. 2012;26(10):1541-1546

[5]Kim E, Noh K, Lee SJ, et al. Simultaneous determination of 3-O-acetyloleanolic acid and oleanolic acid in rat plasma using liquid chromatography coupled to tandem mass spectrometry. J Pharm Biomed Anal. 2016;118:96-100

[6]Hwang-Bo J, Park JH, Chung IS. 3-O-Acetyloleanolic acid inhibits angiopoietin-1-induced angiogenesis and lymphangiogenesis via suppression of angiopoietin-1/Tie-2 signaling. Phytother Res. 2020;34(2):359-367