Butylphthalide, a natural product isolated and purified from the herbs of Ligusticum jeholense with antihypertensive effects, may slow the progression of hypertensive nephropathy by a variety of mechanisms, and is effective for improving cognitive and global functioning in patients with subcortical VCIND and exhibits good safety.
Butylphthalide (3-N-Butylphthalide, NBP), a family of compounds initially isolated from the seeds of Apium graveolens Linn., has shown significant neuroprotective effects[3]. Butylphthalide may inhibit nerve cell apoptosis in rats with cerebral infarction to exert a protective effect, which may be associated with the JNK/p38 MAPK signaling pathway[4]. Butylphthalide has neuroprotective effect on the mouse model of MCAO. It may upregulate the level of miR-21 to inhibit neuronal apoptosis and ROS production and improve the proliferation activity[5]. Butylphthalide injection has a high clinical efficacy in treating hypertensive intracerebral hemorrhages[6]. Butylphthalide combined with conventional treatment can decrease MMP-9 levels and increase VEGF levels[7]. 3-N-butylphthalide (Butylphthalide) administration improved the neuronal morphology in the cerebral cortex and hippocampus of rats with chronic cerebral ischemia, increased choline acetyltransferase activity, and decreased malondialdehyde and amyloid beta levels, and greatly improved cognitive function[8].
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