Senkyunolide I, a natural product isolated and purified from the roots of Ligusticum chuanxiong hort with anti-oxidation and anti-apoptosis properties, is traditionally used to treat migraine, can reduce the metamorphose damage of the RBC caused by ConA, alleviates the aggregation of the RBC, and protect rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3.

Butylphthalide, a natural product isolated and purified from the herbs of Ligusticum jeholense with antihypertensive effects, may slow the progression of hypertensive nephropathy by a variety of mechanisms, and is effective for improving cognitive and global functioning in patients with subcortical VCIND and exhibits good safety.

Senkyunolide H, a natural prototype for an anti-atherosclerotic drug isolated and purified from the roots of Ligusticum chuanxiong hort, can reduce the metamorphose damage of the RBC caused by ConA, and alleviated the aggregation of the RBC.

Senkyunolide A is a natural product isolated and purified from Chinese medical plant Rhizoma Chuanxiong.

Coniferyl ferulate is a natural product.