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3-Butylphthalide

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Chemical Structure| 6066-49-5 同义名 : 丁基苯酞 ;Butylphthalide;3-n-Butylphthalide;rac-3-n-butylphthalide.;NBP;N-butylphthalide;(±)-NBP;(±)-3-Butylphthalide;DL-3-n-Butylphthalide;3-n-Butylphathlide
CAS号 : 6066-49-5
货号 : A963975
分子式 : C12H14O2
纯度 : 98%
分子量 : 190.238
MDL号 : MFCD01704513
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(1314.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(525.66 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Butylphthalide (3-N-Butylphthalide, NBP), a family of compounds initially isolated from the seeds of Apium graveolens Linn., has shown significant neuroprotective effects[3]. Butylphthalide may inhibit nerve cell apoptosis in rats with cerebral infarction to exert a protective effect, which may be associated with the JNK/p38 MAPK signaling pathway[4]. Butylphthalide has neuroprotective effect on the mouse model of MCAO. It may upregulate the level of miR-21 to inhibit neuronal apoptosis and ROS production and improve the proliferation activity[5]. Butylphthalide injection has a high clinical efficacy in treating hypertensive intracerebral hemorrhages[6]. Butylphthalide combined with conventional treatment can decrease MMP-9 levels and increase VEGF levels[7]. 3-N-butylphthalide (Butylphthalide) administration improved the neuronal morphology in the cerebral cortex and hippocampus of rats with chronic cerebral ischemia, increased choline acetyltransferase activity, and decreased malondialdehyde and amyloid beta levels, and greatly improved cognitive function[8].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.26mL

1.05mL

0.53mL

26.28mL

5.26mL

2.63mL

52.57mL

10.51mL

5.26mL
参考文献

[1]Jia J, Wei C, et al. The effects of DL-3-n-butylphthalide in patients with vascular cognitive impairment without dementia caused by subcortical ischemic small vessel disease: A multicentre, randomized, double-blind, placebo-controlled trial. Alzheimers Dement. 2016 Feb;12(2):89-99.

[2]Zhu J, Zhang Y, Yang C. Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats. Mol Med Rep. 2015 Feb;11(2):1448-54.

[3]Abdoulaye IA, Guo YJ. A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives. Biomed Res Int. 2016;2016:5012341

[4]Bu X, Xia W, Wang X, Lu S, Gao Y. Butylphthalide inhibits nerve cell apoptosis in cerebral infarction rats via the JNK/p38 MAPK signaling pathway. Exp Ther Med. 2021 Jun;21(6):565

[5]Zhan L, Pang Y, Jiang H, Zhang S, Jin H, Chen J, Jia C, Guo H, Mu Z. Butylphthalide Inhibits TLR4/NF-κB Pathway by Upregulation of miR-21 to Have the Neuroprotective Effect. J Healthc Eng. 2022 Jan 7;2022:4687349

[6]Wang Y, Yao W, Wang L, Xv D. The effect of butylphthalide injection on the cognitive function and the TLRs/NF-κB pathway in hypertensive intracerebral hemorrhage. Am J Transl Res. 2021 Aug 15;13(8):9578-9585

[7]Xiong Y, Liu J, Xu Y, Xie S, Zhou X, Cheng S. Butylphthalide Combined With Conventional Treatment Attenuates MMP-9 Levels and Increases VEGF Levels in Patients With Stroke: A Prospective Cohort Study. Front Neurol. 2021 Dec 20;12:686199

[8]Zhao W, Luo C, Wang J, Gong J, Li B, Gong Y, Wang J, Wang H. 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia. Neural Regen Res. 2014 Apr 1;9(7):719-26