3'-Azido-3'-deoxythymidine | 叠氮胸苷 | Zidovudine | CRISPR/Cas9 Agonist

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齐多夫定 /3'-Azido-3'-deoxythymidine {[allProObj[0].p_purity_real_show]}

货号：A944627 同义名： 叠氮胸苷 / Zidovudine;Azidothymidine

Zidovudine is a reverse-transcriptase inhibitor (NRTI) that is used to the treat HIV/AIDS infection.

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3'-Azido-3'-deoxythymidine 化学结构
CAS号：30516-87-1

3'-Azido-3'-deoxythymidine 3D分子结构
CAS号：30516-87-1

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3'-Azido-3'-deoxythymidine 纯度/质量文件产品仅供科研

货号：A944627 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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3'-Azido-3'-deoxythymidine 生物活性

描述

Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. It acts by interfering with viral reverse transcriptase, thereby inhibiting human immunodeficiency virus (HIV) replication. Zidovudine inhibits SVG, Primary human fetal astrocytes (PFA), peripheral blood mononuclear cells (PBMC), and monocyte-derived macrophages (MDM) with EC50 of 17, 1311, 8, and 5 nM, respectively. Zidovudine inhibits SVG, PFA, PBMC, and MDM with EC90 of 0.205 μM, 44.157 μM, 0.481 μM, and 0.219 μM, respectively^[3]. Zidovudine reduces the incidence of AIDS dementia complex (ADC) and appears to prolong survival in these patients, and improves other neurological complications of HIV infection^[4]. In acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) patients, orally and intravenously administered zidovudine is effective in reducing the incidence of opportunistic infections and neoplasms, increasing helper T lymphocyte numbers, and improving survival rates and quality of life^[5].

3'-Azido-3'-deoxythymidine 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
AA5 cells		Function assay		Antiviral activity against of Human immunodeficiency virus 1 3B infected in AA5 cells infected with 1.56 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay, IC50=0.3 nM	20086149
C3H/3T3 cells		Function assay		Concentration of compound required to inhibit HIV-1 induced cytopathogenicity of MSV-induced transformation of C3H/3T3 cells by 50%, EC50=0.02 μM	2016718
C8166 cells		Function assay		Inhibition of HIV1-3B replication in C8166 cells, EC50=1.9 nM	16279773
CEM cells		Function assay		Concentration of the drug resulting in 50% reduction of the viral cytopathic effect against HIV-1 replication in CEM cells, EC50=0.32 nM	2153206

3'-Azido-3'-deoxythymidine 参考文献

[1]Panther LA, Coombs RW, et al. Unintegrated HIV-1 circular 2-LTR proviral DNA as a marker of recently infected cells: relative effect of recombinant CD4, zidovudine, and saquinavir in vitro. J Med Virol. 1999 Jun;58(2):165-73.

[2]Chiang G, Sassaroli M, et al. Inhibition of HIV-1 replication by hydroxychloroquine: mechanism of action and comparison with zidovudine. Clin Ther. 1996 Nov-Dec;18(6):1080-92.

[3]Rachlis A, Fanning MM. Zidovudine toxicity. Clinical features and management. Drug Saf. 1993 Apr;8(4):312-20

[4]Wilde MI, Langtry HD. Zidovudine. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 1993 Sep;46(3):515-578

[5]Langtry HD, Campoli-Richards DM. Zidovudine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 1989 Apr;37(4):408-50

3'-Azido-3'-deoxythymidine 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.74mL

0.75mL

0.37mL

18.71mL

3.74mL

1.87mL

37.42mL

7.48mL

3.74mL

3'-Azido-3'-deoxythymidine 技术信息

CAS号	30516-87-1
分子式	C₁₀H₁₃N₅O₄
分子量	267.241

别名	叠氮胸苷 ;Zidovudine;Azidothymidine;brand name Retrovir.;BW A509U;NSC 602670;ZDV;AZT
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 105 mg/mL(392.9 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 15 mg/mL(56.13 mM)，配合低频超声，并水浴加热至45℃助溶

动物实验配方

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

AA5 cells		Function assay		Antiviral activity against of Human immunodeficiency virus 1 3B infected in AA5 cells infected with 1.56 uL of virus stock assessed as inhibition of viral Reverse transcriptase by [3H]TTP incorporation assay, IC50=0.3 nM	20086149
C3H/3T3 cells		Function assay		Concentration of compound required to inhibit HIV-1 induced cytopathogenicity of MSV-induced transformation of C3H/3T3 cells by 50%, EC50=0.02 μM	2016718
C8166 cells		Function assay		Inhibition of HIV1-3B replication in C8166 cells, EC50=1.9 nM	16279773
CEM cells		Function assay		Concentration of the drug resulting in 50% reduction of the viral cytopathic effect against HIV-1 replication in CEM cells, EC50=0.32 nM	2153206
CEM-SS cell		Function assay		Inhibitory activity against the HIV-1-induced cytopathic effect in CEM-SS cell line, IC50=0.002 μM	7650678
human C8166 cells		Function assay		Antiviral activity against Human immunodeficiency virus 1 infected in human C8166 cells assessed as inhibition of virus-induced cytopathic effect, EC50=4e-06 μM	21534540
human H9 cells		Function assay	6 days	Antiviral activity against Human immunodeficiency virus 1 3B infected in human H9 cells infected with 6.25 uL of virus stock assessed as expression of p24 antigen after 6 days postinfection by ELISA, IC50=0.3 nM	20086149
human H9 cells		Cytotoxicity assay	6 days	Cytotoxicity against human H9 cells after 6 days by MTT assay, EC50=0.01 μM	20846868
human lymphocyte CEM/0 cell line		Function assay		Anti HIV-1 activity in human lymphocyte CEM/0 cell line, EC50=0.003 μM	8478904
human MT2 cells		Function assay	1 h	Antiviral activity against HIV1 subtype B-3B infected in 1 hr-pretreated human MT2 cells assessed as inhibition of multicycle replication measured on day 5 postinfection by RT SPA, EC50=1.2 nM	18316521
Jurkat cell		Function assay		Inhibitory concentration against HIV-1 infected Jurkat cell lines, IC50=0.01 μM	7837220
MT4 cells		Function assay	4 days	Antiviral activity against HIV1 3B assessed as inhibition of virus-induced cytopathogenicity in MT4 cells after 4 days by MTT assay, EC50=0.7 nM	17964796
PBLs		Function assay		Antiviral activity against subtype isolate G strain in PBLs (peripheral blood lymphocytes), IC50=0.002 μM	11708913
PBMC	1 μM	Function assay		Antiviral activity against HIV1 TEKI replication in PBMC at 1 uM, IC50=0.00014 μM	16420027
U937 cells		Function assay		Effective concentration required for antiviral activity against Macrophage cell line of U937 cells of Human by XTT assay, EC50=0.03 μM	7932526

齐多夫定 /3'-Azido-3'-deoxythymidine {[allProObj[0].p_purity_real_show]}

3'-Azido-3'-deoxythymidine 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

3'-Azido-3'-deoxythymidine 质控信息

3'-Azido-3'-deoxythymidine 生物活性

3'-Azido-3'-deoxythymidine 细胞研究

3'-Azido-3'-deoxythymidine 参考文献

3'-Azido-3'-deoxythymidine 实验方案

3'-Azido-3'-deoxythymidine 技术信息

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齐多夫定 /3'-Azido-3'-deoxythymidine {[allProObj[0].p_purity_real_show]}

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全球学术期刊中引用的产品

3'-Azido-3'-deoxythymidine 质控信息

3'-Azido-3'-deoxythymidine 生物活性

3'-Azido-3'-deoxythymidine 细胞研究

3'-Azido-3'-deoxythymidine 参考文献

3'-Azido-3'-deoxythymidine 实验方案

3'-Azido-3'-deoxythymidine 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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