货号:A348334
同义名:
2,5-二特丁基对苯二酚
/ BHQ
BHQ is a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
规格 | 价格 | 会员价 | 库存 | 数量 | |||
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快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | ATPase ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(-)-Blebbistatin | 99%+ | ||||||||||||||||||
PF 03716556 |
++++
H+/K+-ATPase, pIC50: ~6.5 |
99%+ | |||||||||||||||||
Esomeprazole sodium | ✔ | 98% | |||||||||||||||||
BTB06584 | ✔ | 99%+ | |||||||||||||||||
Ciclopirox | ✔ | 99%+ | |||||||||||||||||
CB-5083 |
++++
p97 AAA ATPase, IC50: 11 nM |
99%+ | |||||||||||||||||
Ciclopirox olamine | ✔ | 99% | |||||||||||||||||
Brefeldin A |
+++
ATPase (HCT 116), IC50: 0.2 μM |
99%+ | |||||||||||||||||
Oligomycin A | ✔ | 99% | |||||||||||||||||
Sodium orthovanadate |
+++
(Na,K)-ATPase, IC50: 40 nM |
99% | |||||||||||||||||
Golgicide A | ✔ | 99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | The importance of the Ca2+-ATPases of the surface and endoplasmic reticulum membranes in regulating the intracellular Ca2+ concentrations in living cells has been recognized as a result of the development of biophysical techniques and finding of useful pharmacological tool drugs[1]. BHQ is a potent and selective inhibitor of the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA). In rat tail artery myocytes, BHQ reduced ICa(L) in a concentration- and voltage-dependent manner with an IC50 of 66.7 μM[2]. In rat basophilic leukaemia (RBL-2H3) cells under whole cell voltage clamp, a maximal blockade of inward current was obtained within 6 min after perfusion with 10 μM BHQ which caused depolarization of the cell which would affect Ca2+ influx[3]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
4.50mL 0.90mL 0.45mL |
22.49mL 4.50mL 2.25mL |
44.98mL 9.00mL 4.50mL |
CAS号 | 88-58-4 |
分子式 | C14H22O2 |
分子量 | 222.32 |
别名 | 2,5-二特丁基对苯二酚 ;BHQ |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(472.29 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |