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2,5-Di-tert-butylhydroquinone

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Chemical Structure| 88-58-4 同义名 : 2,5-二特丁基对苯二酚 ;BHQ
CAS号 : 88-58-4
货号 : A348334
分子式 : C14H22O2
纯度 : 98%
分子量 : 222.32
MDL号 : MFCD00008825
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(472.29 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 The importance of the Ca2+-ATPases of the surface and endoplasmic reticulum membranes in regulating the intracellular Ca2+ concentrations in living cells has been recognized as a result of the development of biophysical techniques and finding of useful pharmacological tool drugs[1]. BHQ is a potent and selective inhibitor of the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA). In rat tail artery myocytes, BHQ reduced ICa(L) in a concentration- and voltage-dependent manner with an IC50 of 66.7  μM[2]. In rat basophilic leukaemia (RBL-2H3) cells under whole cell voltage clamp, a maximal blockade of inward current was obtained within 6 min after perfusion with 10 μM BHQ which caused depolarization of the cell which would affect Ca2+ influx[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.50mL

0.90mL

0.45mL

22.49mL

4.50mL

2.25mL

44.98mL

9.00mL

4.50mL
参考文献

[1]Furukawa KI. Ca2+-ATPase. Nihon Rinsho. 1996 Mar;54(3):601-6

[2]Fusi F, et al. 2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca2+ channel via superoxide anion generation. Br J Pharmacol. 2001 Aug;133(7):988-96

[3]Hasséssian H, et al. Blockade of the inward rectifier potassium current by the Ca2+-ATPase inhibitor 2',5'-di(tert-butyl)-1,4-benzohydroquinone (BHQ). Br J Pharmacol. 1994 Aug;112(4):1118-22