Isofangchinoline is a bisbenzyltetrahydroisoquinoline alkaloid isolated from Stephania tetrandra, which may be an inactivator of nuclear NR4A1, as well as inhibited cell proliferation and induced apoptosis in human pancreatic cancer cells.
Isofangchinoline (Fangchinoline) is a bisbenzyltetrahydroisoquinoline alkaloid isolated from Stephania tetrandra, which may be an inactivator of nuclear NR4A1, as well as inhibited cell proliferation and induced apoptosis in human pancreatic cancer cells[2]. Fangchinoline inhibited osteoclastogenesis at doses of 0.5 and 1 µM. And fangchinoline down regulated NFATc1 activity and expression. However, fangchinoline did not affect IκBα degradation and MAPK pathways. Fangchinoline could protect against bone loss in OVX mice[3]. Moreover, fangchinoline attenuated the biochemical marker changes induced by DN (diabetic nephropathy) in blood and urine. The expression of p38 MAPK, TNF-α, COX-2, and MMP-9 was also attenuated by fangchinoline treatment in the kidney tissues of DN rats[4]. FAN (Fangchinoline) decreased the production of inflammatory cytokines and ROS in human FLS cells as well as the phosphorylation of the MAPK pathway and NF-κB pathway in human FLS (fibroblast-like synovial cells) cells. The behavioral parameters in the C/K rat model and CIA (collagen-induced arthritis) mouse model and inflammatory signs in the histological analysis were found to be ameliorated in FAN-treated groups. Cartilage degradation in CIA mice knee joints were shown to have been suppressed by FAN[5].
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