(R)-Fangchinoline
产品说明书
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同义名 : | 防己醇灵 ;Thaligine;Thalrugosine;(+)-Limacine, 7-O-Demethyltetrandine;Isofangchinoline;NSC 277171;(R)-Fangchinoline |
| CAS号 : | 33889-68-8 | |
| 货号 : | A626874 | |
| 分子式 : | C37H40N2O6 | |
| 纯度 : | 97% | |
| 分子量 : | 608.723 | |
| MDL号 : | MFCD00221726 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(82.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Isofangchinoline (Fangchinoline) is a bisbenzyltetrahydroisoquinoline alkaloid isolated from Stephania tetrandra, which may be an inactivator of nuclear NR4A1, as well as inhibited cell proliferation and induced apoptosis in human pancreatic cancer cells[2]. Fangchinoline inhibited osteoclastogenesis at doses of 0.5 and 1 µM. And fangchinoline down regulated NFATc1 activity and expression. However, fangchinoline did not affect IκBα degradation and MAPK pathways. Fangchinoline could protect against bone loss in OVX mice[3]. Moreover, fangchinoline attenuated the biochemical marker changes induced by DN (diabetic nephropathy) in blood and urine. The expression of p38 MAPK, TNF-α, COX-2, and MMP-9 was also attenuated by fangchinoline treatment in the kidney tissues of DN rats[4]. FAN (Fangchinoline) decreased the production of inflammatory cytokines and ROS in human FLS cells as well as the phosphorylation of the MAPK pathway and NF-κB pathway in human FLS (fibroblast-like synovial cells) cells. The behavioral parameters in the C/K rat model and CIA (collagen-induced arthritis) mouse model and inflammatory signs in the histological analysis were found to be ameliorated in FAN-treated groups. Cartilage degradation in CIA mice knee joints were shown to have been suppressed by FAN[5]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.64mL 0.33mL 0.16mL |
8.21mL 1.64mL 0.82mL |
16.43mL 3.29mL 1.64mL |
| 参考文献 |
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