Ambeed.cn

首页 / / / / (E)-5-(2-Bromovinyl)-2'-deoxyuridine

溴夫定 /(E)-5-(2-Bromovinyl)-2'-deoxyuridine {[allProObj[0].p_purity_real_show]}

货号:A320199 同义名: 溴夫定 / Brivudine;Bromovinyldeoxyuridine Ambeed 开学季,买赠积分,赢豪礼

Brivudine is an antiviral drug acts by inhibiting replication of the target virus, used in the treatment of Herpes Zoster.

(E)-5-(2-Bromovinyl)-2'-deoxyuridine 化学结构 CAS号:69304-47-8
(E)-5-(2-Bromovinyl)-2'-deoxyuridine 化学结构
CAS号:69304-47-8
(E)-5-(2-Bromovinyl)-2'-deoxyuridine 3D分子结构
CAS号:69304-47-8
(E)-5-(2-Bromovinyl)-2'-deoxyuridine 化学结构 CAS号:69304-47-8
(E)-5-(2-Bromovinyl)-2'-deoxyuridine 3D分子结构 CAS号:69304-47-8
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

(E)-5-(2-Bromovinyl)-2'-deoxyuridine 纯度/质量文件 产品仅供科研

货号:A320199 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

全球学术期刊中引用的产品

JACS Au, 2024. Ambeed. [ A148168 ]
JMC, 2024. Ambeed. [ A187643 ]
JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]
Biomacromolecules, 2024. Ambeed. [ A110759 ]
Biomacromolecules, 2024. Ambeed. [ A203543 ]
更多 >
产品名称 DNA-PK 其他靶点 纯度
PI-103 ++

DNA-PK, IC50: 23 nM

{[allProObj[0].p_purity_real_show]}
CC-115 +++

DNA-PK, IC50: 0.013 μM

mTOR {[allProObj[0].p_purity_real_show]}
Samotolisib {[allProObj[0].p_purity_real_show]}
NU 7026 +

DNA-PK, IC50: 0.23 μM

PI3K {[allProObj[0].p_purity_real_show]}
PIK-75 HCl ++++

DNA-PK, IC50: 2 nM

{[allProObj[0].p_purity_real_show]}
PP121 +

DNA-PK, IC50: 60 nM

VEGFR,PDGFR {[allProObj[0].p_purity_real_show]}
KU-0060648 ++++

DNA-PK, IC50: 5 nM

{[allProObj[0].p_purity_real_show]}
KU-57788 +++

DNA-PK, IC50: 14 nM

{[allProObj[0].p_purity_real_show]}
LTURM34 ++

DNA-PK, IC50: 0.034 μM

{[allProObj[0].p_purity_real_show]}
SF2523 +++

DNA-PK, IC50: 9 nM

{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

(E)-5-(2-Bromovinyl)-2'-deoxyuridine 生物活性

描述 Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir[3]. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage. Oral brivudin is generally well tolerated, with a similar tolerability profile to those of oral acyclovir or famciclovir. Nausea was the most commonly reported adverse event[4]. As opposed to the others, brivudine is a non-nephrotoxic drug that should not be administered to immunodepressed patients or to those being treated with 5-fluorouracil[5].

(E)-5-(2-Bromovinyl)-2'-deoxyuridine 参考文献

[1]Buturak A, Norgaz T, et al. Brivudine induced coronary vasospasm as a manifestation of Kounis syndrome: First report. Int J Cardiol. 2015 Apr 15;185:4-6.

[2]Gonen I, Turan H, et al. Brivudin induced delirium: a case report. J Chemother. 2012 Aug;24(4):229-30.

[3]Rabasseda X. Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Drugs Today (Barc). 2003 May;39(5):359-71

[4]Keam SJ, Chapman TM, Figgitt DP. Brivudin (bromovinyl deoxyuridine). Drugs. 2004;64(18):2091-7; discussion 2098-9

[5]España A, Redondo P. Actualización en el tratamiento del herpes zóster [Update in the treatment of herpes zoster]. Actas Dermosifiliogr. 2006 Mar;97(2):103-14. Spanish

(E)-5-(2-Bromovinyl)-2'-deoxyuridine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.00mL

0.60mL

0.30mL

15.01mL

3.00mL

1.50mL

30.02mL

6.00mL

3.00mL

(E)-5-(2-Bromovinyl)-2'-deoxyuridine 技术信息

CAS号69304-47-8
分子式C11H13BrN2O5
分子量 333.135
别名 溴夫定 ;Brivudine;Bromovinyldeoxyuridine;BVDU
运输蓝冰
存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 190 mg/mL(570.34 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
  • 客户支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务,不为任何个人或者非科研性质用途提供服务。