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次水杨酸铋 /Bismuth Subsalicylate {[allProObj[0].p_purity_real_show]}

货号:A107682 同义名: 碱式水杨酸铋 / Bismuth(III) salicylate basic;Bismuth oxysalicylate

Bismuth subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.

Bismuth Subsalicylate 化学结构 CAS号:14882-18-9
Bismuth Subsalicylate 化学结构
CAS号:14882-18-9
Bismuth Subsalicylate 3D分子结构
CAS号:14882-18-9
Bismuth Subsalicylate 化学结构 CAS号:14882-18-9
Bismuth Subsalicylate 3D分子结构 CAS号:14882-18-9
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Bismuth Subsalicylate 纯度/质量文件 产品仅供科研

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Bismuth Subsalicylate 生物活性

描述 Bismuth subsalicylate is an orally active, antacid, anti-diarrheal, anti-inflammatory agent used for symptomatic treatment of gastrointestinal discomfort including upset stomach and traveler’s diarrhea for adults and children over 12 years old[3]. Pre-treatment of rats with bismuth subsalicylate (17.7mg, intragastric gavage) reversed indomethacin (60mg/kg)-induced decrease in pHi during acid superfusion without affecting gel thickness. Bismuth subsalicylate had no effect on pHi when rats were treated with indomethacin a non-ulcerogenic but prostaglandin-inhibiting dose (5mg/kg)[4].

Bismuth Subsalicylate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02386813 - Completed - Korea, Republic of ... 展开 >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 Samsung Medical Center Seoul, Korea, Republic of, 135710 收起 <<
NCT01195051 Medication Reconciliation Phase 3 Completed - United States, Indiana ... 展开 >> Wishard Hospital Indianapolis, Indiana, United States, 46202 收起 <<
NCT02364466 - Recruiting December 2019 Korea, Republic of ... 展开 >> Dankook University Hospital Not yet recruiting Cheonan, Korea, Republic of Keimyung University Dongsan Hospital Not yet recruiting Daegu, Korea, Republic of Contact: Young Rok Do          Yeungnam University Hospital Not yet recruiting Daegu, Korea, Republic of Hanyang University Guri Hospital Not yet recruiting Guri, Korea, Republic of Inje University Ilsan Paik Hospital Not yet recruiting Ilsan, Korea, Republic of National Health and Insurance Service Ilsan Hospital Not yet recruiting Ilsan, Korea, Republic of Kosin Universithy Gospel Hospital Not yet recruiting Pusan, Korea, Republic of Pusan National University Hospital Not yet recruiting Pusan, Korea, Republic of Korea Cancer Center Hospital Recruiting Seoul, Korea, Republic of, 139-706 Contact: Dong-Yeop Shin, M.D.    +82-2970-1246    baramg@hanmail.net    Asan Medical Center Recruiting Seoul, Korea, Republic of Contact: Dok Hyun Yoon, M.D.,Ph.D.          Choong Ang University Hospital Not yet recruiting Seoul, Korea, Republic of Hallym University Hospital Not yet recruiting Seoul, Korea, Republic of Hanyang University Hospital Not yet recruiting Seoul, Korea, Republic of Samsung Medical Center Recruiting Seoul, Korea, Republic of Contact: Won Seog Kim, M.D., Ph.D.          Seoul National University Hospital Not yet recruiting Seoul, Korea, Republic of Soonchunhyang University Hospital Not yet recruiting Seoul, Korea, Republic of Ajou University Hospital Recruiting Suwon, Korea, Republic of Contact: Seong Hyun Jeong, M.D.,Ph.D.          Ulsan University Hospital Not yet recruiting Ulsan, Korea, Republic of 收起 <<

Bismuth Subsalicylate 参考文献

[1]Bierer DW. Bismuth subsalicylate: history, chemistry, and safety. Rev Infect Dis. 1990 Jan-Feb;12 Suppl 1:S3-8.

[2]Sox TE, Olson CA. Binding and killing of bacteria by bismuth subsalicylate. Antimicrob Agents Chemother. 1989 Dec;33(12):2075-82. PubMed PMID: 2694949; PubMed Central PMCID: PMC172824.

[3]Budisak p, Abbas M. Bismuth Subsalicylate. Treassure Island (FL): StstPearls Publishing: 2022 Jan.

[4]Tanaka S, Guth PH, Carryl OR, Kaunitz JD. Cytoprotective effect of bismuth subsalicylate in indomethacin-treated rats is associated with enhanced mucus bismuth concentration. Aliment Pharmacol Ther. 1997;11(3):605-612.

Bismuth Subsalicylate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.76mL

0.55mL

0.28mL

13.81mL

2.76mL

1.38mL

27.62mL

5.52mL

2.76mL

Bismuth Subsalicylate 技术信息

CAS号14882-18-9
分子式C7H5BiO4
分子量 362.093
别名 碱式水杨酸铋 ;Bismuth(III) salicylate basic;Bismuth oxysalicylate;Bismuth oxide salicylate
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度
动物实验配方
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