Sinensetin is a methylated flavone isolated and purified from the fruit of Citrus aurantium L. with antimutagenic, anticancer, and anti-inflammatory activities.
Sinensetin is a methylated flavone found in certain citrus fruits. Sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels in adipocytes[3]. Sin (Sinensetin) may inhibit chondrocyte apoptosis induced by tert-butyl hydroperoxide (TBHP); at the same time, it might also inhibit the production of MMP13 and promote the production of aggrecan and collagen II. Sin promotes chondrocyte autophagy by activating AMPK/mTOR signaling pathway[4]. SIN significantly induced cell death in HepG2 cells, whereas the proliferation rate of Thle2, human liver epithelial cells, was unaffected by SIN[5]. Sinensetin has potential capacity to attenuate IAV (influenza A virus)-triggered pro-inflammatory response via inactivation of NF-κB, ERK1/2 MAPK and p38 MAPK signalings[6].
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