GNE0877 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitor with an IC50 of 3 nM.

EB-42486 是一种新型、高选择性的G2019S-LRRK2抑制剂，IC50 < 0.2 nM。

CZC-25146 is a potent LRRK2 inhibitor with IC50 values of 4.76 and 6.87 nM for for wild-type and G2019S mutant LRRK2, respectively. It also inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2.

PFE-360是一种选择性的 LRRK2 抑制剂，能够有效透过血脑屏障，对神经退行性疾病具有潜在的研究价值。

CZC-54252 HCl是一种选择性的 LRRK2 抑制剂，显示出对 G2019S LRRK2 突变体的神经保护作用，广泛用于神经退行性疾病（如帕金森病）的研究。

GSK2578215A is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2, respectively.

CZC-54252 is a potent LRRK2 inhibitor with IC50 values of 1.28 nM and 1.85 nM for wild-type and G2019S mutant LRRK2, respecitively, possessing neuroprotective effect.

MLi-2 is a highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity.

GNE-7915是一种高度选择性和能穿透血脑屏障的LRRK2抑制剂，其IC50值为9 nM。

LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 values of 6 and 13 nM for G2019S mutant and wild-type LRRK2, respectively.

GNE-9605 is a selective and potent LRRK2 with IC50 value of 18.7 nM.

PF-06447475 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 3 nM, possessing neuroprotective activity.

IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.

PF-06371900 is a selective LRRK2 inhibitor with IC50 value of 64nM.

JH-II-127 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 2.2, 6.6 and 47.7 nM for G2019S-mutant, wild-type and A2016T-mutant LRRK2, respectively.