KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM.

Camonsertib是一种高选择性的ATR激酶抑制剂(ATRi)，能够有效抑制ATR的活性，在抗肿瘤研究中显示出显著的效果。

Berzosertib（VE-822）以小于0.2 nM的Ki值抑制ATR，也以34 nM的Ki值抑制ATM。

AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities.

BAY-1895344 is a potent and selective ATR inhibitor with IC50 of 7 nM.

KU-55933是一种高效的 ATM 抑制剂，其 IC50 和 Ki 值分别为 12.9 nM 和 2.2 nM，与 DNA-PK、PI3K/PI4K、ATR 和 mTOR 相比，对 ATM 的选择性极高。

AZ32 is an ATM inhibitor with IC50 <6.2 nM in enzyme assays and 310 nM in cellular assays.

AZ 20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM exhibiting 8-fold selectivity over mTOR (IC50=38 nM).

CGK 733 is an inhibitor of ATM and ATR with IC50 of ~200 nM, also induces cell death in prematurely senescent breast cancer cells.

AZD1390 is an ATM inhibitor with IC50 of 0.78 nM in cells.

Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.

Ceralasertib (AZD6738) 是一种口服活性和生物利用度高的 ATR 激酶抑制剂，IC50 为 1 nM。

VE-821是一种高效的 ATP 竞争性 ATR 抑制剂，其 Ki/IC50 值分别为 13 nM/26 nM。

ATR inhibitor 2 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity[1][2].

CP-466722, a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells.

Dactolisib（BEZ235）是一种口服活性的双重抑制剂，对pan-class I PI3K和mTOR激酶的IC50值分别为4 nM、5 nM、7 nM和75 nM，对mTOR的IC50值为20.7 nM。Dactolisib抑制mTORC1和mTORC2。

ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC50= 0.6, 14, 36, 170, and 545 nM, respectively).

Wortmannin（SL-2052；KY-12420）是一种有效、选择性和不可逆的PI3K抑制剂，IC50为3 nM。它还阻止自噬形成，强效抑制Polo样激酶1（PlK1）和Plk3的IC50分别为5.8 nM和48 nM。

PI-103 is a potent inhibitor with low IC50 values against recombinant PI3K isoforms p110alpha (IC50= 2 nM), p110beta (IC50= 3 nM), p110delta (IC50= 3 nM), and p110gamma (IC50= 15 nM), less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. It blocks autophagic flux.

Torin 2是一种mTOR抑制剂，抑制细胞mTOR活性的EC50为0.25 nM，表现出对PI3K的800倍选择性（EC50：200 nM），并在无细胞试验中以0.5 nM的IC50抑制DNA-PK。Torin 2抑制mTORC1和mTORC2。