KU-55933是一种高效的 ATM 抑制剂，其 IC50 和 Ki 值分别为 12.9 nM 和 2.2 nM，与 DNA-PK、PI3K/PI4K、ATR 和 mTOR 相比，对 ATM 的选择性极高。

Wortmannin（SL-2052；KY-12420）是一种有效、选择性和不可逆的PI3K抑制剂，IC50为3 nM。它还阻止自噬形成，强效抑制Polo样激酶1（PlK1）和Plk3的IC50分别为5.8 nM和48 nM。

Torin 2是一种mTOR抑制剂，抑制细胞mTOR活性的EC50为0.25 nM，表现出对PI3K的800倍选择性（EC50：200 nM），并在无细胞试验中以0.5 nM的IC50抑制DNA-PK。Torin 2抑制mTORC1和mTORC2。

CP-466722, a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells.

ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC50= 0.6, 14, 36, 170, and 545 nM, respectively).

CGK 733 is an inhibitor of ATM and ATR with IC50 of ~200 nM, also induces cell death in prematurely senescent breast cancer cells.

AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities.