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Mirin {[allProObj[0].p_purity_real_show]}

货号：A248394

Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.

Mirin 化学结构
CAS号：1198097-97-0

Mirin 3D分子结构
CAS号：1198097-97-0

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Mirin 纯度/质量文件产品仅供科研

货号：A248394 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

ATM/ATR 亚型比较

产品名称	ATM ↓ ↑	ATR ↓ ↑	其他靶点	纯度
Wortmannin	++ ATM, IC50: 150 nM		PI3K,DNA-PK,MLCK	99%+
CP-466722	+ ATM, IC50: 410 nM			99%+
Torin 2	++ ATM, EC50: 28 nM	++ ATR, EC50: 35 nM	mTOR,DNA-PK	99%+
KU-55933	+++ ATM, IC50: 12.9 nM			96%
ETP-46464	+ ATM, IC50: 545 nM	+++ ATR, IC50: 14 nM	mTOR,DNA-PK	98%
CGK733	++ ATM, IC50: 200 nM	++ ATR, IC50: 200 nM		99%+
AZD0156	✔			99%+
Dactolisib		+++ ATR, IC50: 21 nM		98+%
Ceralasertib		++++ ATR, IC50: 1 nM		99%+
Berzosertib		+++ ATR, IC50: 19 nM		99%+
VE-821		+++ ATR, Ki: 13 nM		99%+
AZ20		++++ ATR, IC50: 5 nM	mTOR	99%+
Schizandrin B		+ ATR, IC50: 7.25 μM	P-gp	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Mirin 生物活性

描述

(Z)-Mirin functions as an inhibitor targeting the MRN complex, comprising Mre11, Rad50, and Nbs1, thereby obstructing the MRN-mediated initiation of ATM activation without influencing the kinase activity of ATM itself. It effectively suppresses the exonuclease activity associated with Mre11. The compound enhances apoptosis, induces a G2/M cell cycle arrest, and significantly diminishes the efficiency of homology-directed repair (HDR)^[1].^[2].

体外研究

At varying concentrations (50, 100, 500 μM), (Z)-Mirin curtails the ATM-dependent phosphorylation of Nbs1 and Chk2, along with the MRN-induced autophosphorylation of ATM at Ser1981 following DNA double-strand breaks (DSBs). A concentration of 100 μM of (Z)-Mirin is noted for its capacity to inhibit the nuclease functionality of Mre11^[1].

Exposure to (Z)-Mirin ranging from 10 to 100 μM for 24 hours demonstrates a median cytotoxicity threshold at 50 μM in HEK293 cells^[1].

Concentrations of 50 μM and 100 μM of (Z)-Mirin are reported to induce significant G2 phase arrest^[1].

Furthermore, application of (Z)-Mirin at 18 µM for a duration of 48 hours leads to an upsurge in apoptotic activity within PEO4 cells^[2].

Mirin 参考文献

[1]Rozier L, et al. The MRN-CtIP pathway is required for metaphase chromosome alignment. Mol Cell. 2013 Mar 28;49(6):1097-107.

[2]Lee JH, et al. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem. 2013 May 3;288(18):12840-51.

Mirin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

4.54mL

0.91mL

0.45mL

22.70mL

4.54mL

2.27mL

45.40mL

9.08mL

4.54mL

Mirin 技术信息

CAS号	1198097-97-0
分子式	C₁₀H₈N₂O₂S
分子量	220.248

别名
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 30 mg/mL(136.21 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

Mirin {[allProObj[0].p_purity_real_show]}

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Mirin {[allProObj[0].p_purity_real_show]}

Mirin 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Mirin 质控信息

Mirin 生物活性

Mirin 参考文献

Mirin 实验方案

Mirin 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Mirin 纯度/质量文件产品仅供科研