At varying concentrations (50, 100, 500 μM), (Z)-Mirin curtails the ATM-dependent phosphorylation of Nbs1 and Chk2, along with the MRN-induced autophosphorylation of ATM at Ser1981 following DNA double-strand breaks (DSBs). A concentration of 100 μM of (Z)-Mirin is noted for its capacity to inhibit the nuclease functionality of Mre11^[1].

Exposure to (Z)-Mirin ranging from 10 to 100 μM for 24 hours demonstrates a median cytotoxicity threshold at 50 μM in HEK293 cells^[1].

Concentrations of 50 μM and 100 μM of (Z)-Mirin are reported to induce significant G2 phase arrest^[1].

Furthermore, application of (Z)-Mirin at 18 µM for a duration of 48 hours leads to an upsurge in apoptotic activity within PEO4 cells^[2].