Lenalidomide, a analog of thalidomide, is TNF-α secretion inhibitor with IC50 of 13 nM.

Pomalidomide是一种第三代免疫调节剂，通过与 E3 连接酶 cereblon 相互作用并诱导必需的 Ikaros 转录因子降解，作为分子胶作用。

Necrostatin-1 is an inhibitor of RIP1 and can decrease TNF-α-induced necroptosis with EC50 of 490 nM.

QNZ（EVP4593）对NF-κB转录激活和TNF-α生成具有强效抑制作用，IC50值分别为11 nM和7 nM。QNZ（EVP4593）是一种神经保护性的SOC通道抑制剂。

Apremilast is a small molecule inhibitor of PDE4 with an IC50 value of 74 nM.

GSK2982772 is an inhibitor of receptor interacting protein 1 (RIP1) with IC50 of 16 nM and it is used for the treatment of inflammatory diseases.

Acetylcysteine is an inhibitor of ROS and the production of TNF. It is a pharmaceutical drug and nutritional supplement used as mucolytic agent.

Adalimumab是一种人源化IgG1单克隆抗体，通过与TNFα结合来阻止其与受体结合。Adalimumab具有用于类风湿性关节炎、克罗恩病和牛皮癣研究的潜力。

GSK'481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells.

Thalidomide targets to CRBN with IC50 of 8.5 nM. It can inhibit biosynthesis of TNF-α and has anti-angiogenic and immunosuppressive effects.