ONO-7475 is a potent and selective inhibitor of active novel Axl/Mer tyrosine kinase with IC50 values of 0.7nM and 1nM, respectively. It potently arrested growth and induced apoptosis in acute myeloid leukemia with internal tandem duplication mutation of FMS-like tyrosine kinase 3.

SC13 specifically inhibits FEN1 activity. It suppresses cancer cell proliferation and induces chromosome instability and cytotoxicity in cells, as well as sensitizes cancer cells to DNA damage-inducing therapeutic modalities and impedes cancer progression in a mouse model.

UNC2541是一种特异性 MerTK 抑制剂，对 MerTK ATP 结合口袋具有高亲和力。它在抑制磷酸化的 MerTK 和相关癌症研究中具有潜在应用。

RXDX-106 inhibits TAM and c-MET phosphorylation in vitro. This inhibition of TAM and c-MET activation in vitro is accompanied by a decrease in downstream MAPK and PI3K signaling and cell viability. It completely inhibits cellular proliferation and viability at sub-nanomolar concentrations in TAM-expressing cells.

TP-0903 is a selective Axl kinase inhibitor with IC50 of 27 nM.

UNC2250 is an inhibitor of Mer with IC50 of 1.7 nM.

LDC1267 is a selective inhibitor of TAM and inhibits Tyro3, Axl and Mer with IC50 of < 5 nM, 8 nM, 29 nM, respectively.

Cabozantinib S-malate (XL184 S-malate) 是一种多受体酪氨酸激酶的强效抑制剂，包括 VEGFR2、c-Met、Kit、Axl 和 Flt3，IC50 值分别为 0.035、1.3、4.6、7 和 11.3 nM。

Gilteritinib (ASP2215) 是一种强效和 ATP 竞争性的 FLT3/AXL 抑制剂，IC50 值分别为 0.29 nM 和 0.73 nM。

BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, being 40-fold selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.

NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.

SGI-7079, a selective Axl inhibitor, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance.

Bemcentinib (R428)是一种口服活性和选择性的 Axl 抑制剂，IC50 为 14 nM。

UNC2881 is a Mer kinase inhibitor and can inhibit the phosphorylation of Mer with IC50 of 4.3 nM.