SC13 specifically inhibits FEN1 activity. It suppresses cancer cell proliferation and induces chromosome instability and cytotoxicity in cells, as well as sensitizes cancer cells to DNA damage-inducing therapeutic modalities and impedes cancer progression in a mouse model.

UNC2541是一种特异性 MerTK 抑制剂，对 MerTK ATP 结合口袋具有高亲和力。它在抑制磷酸化的 MerTK 和相关癌症研究中具有潜在应用。

RXDX-106 inhibits TAM and c-MET phosphorylation in vitro. This inhibition of TAM and c-MET activation in vitro is accompanied by a decrease in downstream MAPK and PI3K signaling and cell viability. It completely inhibits cellular proliferation and viability at sub-nanomolar concentrations in TAM-expressing cells.

TP-0903 is a selective Axl kinase inhibitor with IC50 of 27 nM.

UNC2250 is an inhibitor of Mer with IC50 of 1.7 nM.

LDC1267 is a selective inhibitor of TAM and inhibits Tyro3, Axl and Mer with IC50 of < 5 nM, 8 nM, 29 nM, respectively.

ONO-7475 is a potent and selective inhibitor of active novel Axl/Mer tyrosine kinase with IC50 values of 0.7nM and 1nM, respectively. It potently arrested growth and induced apoptosis in acute myeloid leukemia with internal tandem duplication mutation of FMS-like tyrosine kinase 3.

Cabozantinib S-malate (XL184 S-malate) 是一种多受体酪氨酸激酶的强效抑制剂，包括 VEGFR2、c-Met、Kit、Axl 和 Flt3，IC50 值分别为 0.035、1.3、4.6、7 和 11.3 nM。

Gilteritinib (ASP2215) 是一种强效和 ATP 竞争性的 FLT3/AXL 抑制剂，IC50 值分别为 0.29 nM 和 0.73 nM。

BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, being 40-fold selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.

NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.

SGI-7079, a selective Axl inhibitor, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance.

Bemcentinib (R428)是一种口服活性和选择性的 Axl 抑制剂，IC50 为 14 nM。

UNC2881 is a Mer kinase inhibitor and can inhibit the phosphorylation of Mer with IC50 of 4.3 nM.

S49076 is a potent inhibitor of MET, AXL/MER, and FGFRs.