Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
肿瘤
/
蛋白质酪氨酸激酶
肿瘤生长增殖和凋亡
/
c-Met/HGFR
TAM受体
/ NPS-1034

NPS-1034 {[allProObj[0].p_purity_real_show]}

货号：A518169

NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.

NPS-1034 化学结构 CAS号：1221713-92-3
NPS-1034 化学结构
CAS号：1221713-92-3
NPS-1034 3D分子结构
CAS号：1221713-92-3
NPS-1034 化学结构 CAS号：1221713-92-3
NPS-1034 3D分子结构 CAS号：1221713-92-3
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

NPS-1034 纯度/质量文件 产品仅供科研

货号：A518169 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Cell Host Microbe, 2024. Ambeed. [ A163338 ]
• Cancer Res., 2024. Ambeed. [ A295334 ]
• J. Pharm. Investig., 2024. Ambeed. [ A221527 , A691302 , A272538 , A187261 ]
• J. Fungi, 2024, 10(11): 751. Ambeed. [ A796919 ]
• JBC, 2024, 107935. Ambeed. [ A194396 ]
更多 >

NPS-1034 生物活性

描述 NPS-1034 serves as a dual antagonist for AXL and MET, exhibiting IC50 values of 10.3 nM for AXL and 48 nM for MET. In HCC827/ER cells, where AXL's expression and activity are notably heightened, treatment with NPS-1034 successfully curtails its tyrosine phosphorylation. NPS-1034 reduces the viability of MKN45 and SNU638 cell lines, which have high expression levels of the MET gene and phosphorylated MET, with IC50 values of 112.7 nM and 190.3 nM, respectively. Conversely, it inhibits the viability of AGS, KATOIII, NCI-N87, MKN1, MKN28, and MKN74 cell lines with IC50 values ranging from 1 μM to over 10 μM. Treatment with NPS-1034 significantly lowers MET phosphorylation in MKN45 cells, but not in MKN28 cells. It also inhibits HGF-induced MET autophosphorylation in AGS and MKN1 cell lines with IC50 values of less than 10 nM and less than 50 nM, respectively, with 50 nM of NPS-1034 completely blocking HGF-induced MET phosphorylation[1].

NPS-1034 动物研究

Animal study NPS-1034 suppresses tumor growth in tumors that express high levels of phosphorylated MET and leads to a notable reduction in tumor vascularization. The expression of α-SMA is also reduced in the tumor sections of mice treated with NPS-1034. Mice treated with NPS-1034 exhibit no significant weight loss, suggesting that the compound is generally well-tolerated[2].

NPS-1034 参考文献

[1]Rho JK, et al. MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to EGFR kinase inhibitors because of MET or AXL activation. Cancer Res. 2014 Jan 1;74(1):253-62.

[2]Shin JS, et al. NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants. Invest New Drugs. 2014 Jun;32(3):389-99.

NPS-1034 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.81mL

0.36mL

0.18mL

9.07mL

1.81mL

0.91mL

18.13mL

3.63mL

1.81mL

NPS-1034 技术信息

CAS号1221713-92-3
分子式C31H23F2N5O3
分子量 551.543
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C
溶解度

DMSO: 35 mg/mL(63.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: NPS-1034 | 1221713-92-3 | NPS1034 | NPS 1034 | AXL/MET Inhibitor | Protein Tyrosine Kinase/RTK | Apoptosis | TAM Receptor | c-Met/HGFR | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | NPS-1034 纯度/质量文件 | NPS-1034 生物活性 | NPS-1034 动物研究 | NPS-1034 参考文献 | NPS-1034 实验方案 | NPS-1034 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z