NSC 74859 (S3I-201) 是一种选择性 Stat3 抑制剂，IC50 为 86 μM。

Stattic是一种有效的STAT3抑制剂，有效抑制STAT3磷酸化（在Y705和S727）。它还抑制高亲和力磷酸肽与STAT3的SH2结构域的结合，并改善Alport综合征（AS）小鼠的肾功能障碍。

Niclosamide（BAY2353）是一种口服活性抗蠕虫剂，用于寄生虫感染研究。它是STAT3抑制剂，在HeLa细胞中的IC50为0.25 μM，具有抗癌生物活性，抑制Vero E6细胞中的DNA复制。

C188-9 is a STAT3 inhibitor and has no effects on non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in mice.

BP-1-102 is an orally available, small-molecule inhibitor of transcription factor STAT3.

SH-4-54 is a potent, small molecule, nonphosphorylated STAT3 inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.

Cryptotanshinone是一种从丹参根中提取的天然化合物，通过抑制 STAT3 表现出抗肿瘤活性，IC50 为 4.6 μM。

HJC0152 inhibits STAT3 promoter activity in MDA-MB-231 cells in a dose-dependent manner.

STA-21 is a selective STAT3 inhibitor.

Napabucasin（BBI608）是一种STAT3抑制剂，阻断癌细胞中的干细胞活性。

HO-3867 selectively inhibits the phosphorylation and transcription of STAT3. It is an analog of curcumin.

Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and EXP1 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro.

SH5-07 is an inhibitor of STAT3 with IC50 of 3.9±0.6 μM with antitumor effects and it can suppresse human glioma and breast cancer.