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Fosciclopirox {[allProObj[0].p_purity_real_show]}

货号:A1516314 同义名: CPX-POM

Fosciclopirox是 γ-分泌酶(γ-secretase)抑制剂,具有抗尿路上皮癌的潜力,通过靶向 γ-分泌酶来抑制癌细胞生长。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Fosciclopirox 化学结构 CAS号:1380539-06-9
Fosciclopirox 化学结构
CAS号:1380539-06-9
Fosciclopirox 3D分子结构
CAS号:1380539-06-9
Fosciclopirox 化学结构 CAS号:1380539-06-9
Fosciclopirox 3D分子结构 CAS号:1380539-06-9
规格 价格 会员价 库存 数量
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Fosciclopirox 纯度/质量文件 产品仅供科研

货号:A1516314 标准纯度: {[allProObj[0].p_purity_real_show]}
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Fosciclopirox 生物活性

描述 Fosciclopirox inhibits urothelial cancer growth by targeting the γ-secretase complex.Fosciclopirox selectively delivers the active metabolite, Ciclopirox (CPX), throughout the urinary tract[1][2].Fosciclopirox has anticancer activity against a wide range of solid tumours and haematological malignancies.

Fosciclopirox 参考文献

[1]Weir SJ, Dandawate P, Standing D, Bhattacharyya S, Ramamoorthy P, Rangarajan P, Wood R, Brinker AE, Woolbright BL, Tanol M, Ham T, McCulloch W, Dalton M, Reed GA, Baltezor MJ, Jensen RA, Taylor JA 3rd, Anant S. Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex. Cell Death Dis. 2021 May 31;12(6):562.

[2]Weir SJ, Wood R, Schorno K, Brinker AE, Ramamoorthy P, Heppert K, Rajewski L, Tanol M, Ham T, McKenna MJ, McCulloch W, Dalton M, Reed GA, Jensen RA, Baltezor MJ, Anant S, Taylor JA 3rd. Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs. J Pharmacol Exp Ther. 2019 Aug;370(2):148-159.

Fosciclopirox 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.15mL

0.63mL

0.32mL

15.76mL

3.15mL

1.58mL

31.52mL

6.30mL

3.15mL

Fosciclopirox 技术信息

CAS号1380539-06-9
分子式C13H20NO6P
分子量 317.275
别名 CPX-POM
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C

溶解度

DMSO: 105 mg/mL(330.94 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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