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络石苷 /tracheloside {[allProObj[0].p_purity_real_show]}

货号:A333342

tracheloside是一种天然产物,显著降低碱性磷酸酶(AP)活性,这是一种雌激素诱导的标志酶,其IC50值为0.31 mg/mL,与他莫昔芬(IC50 = 0.43 mg/mL)相当。

tracheloside 化学结构 CAS号:33464-71-0
tracheloside 化学结构
CAS号:33464-71-0
tracheloside 3D分子结构
CAS号:33464-71-0
tracheloside 化学结构 CAS号:33464-71-0
tracheloside 3D分子结构 CAS号:33464-71-0
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tracheloside 纯度/质量文件 产品仅供科研

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tracheloside 生物活性

描述 Tracheloside is a lignan glycoside isolated from the seeds of Trachelospermum jasminoides with anti-estrogenic activity. It has been shown to decreased the activity of alkaline phosphatase in Ishiwaka cells with an IC50 value of 0.31μg/mL[3]. Treatment of HaCaT cells with tracheloside at 1, 5, and 10μg/mL increased cell proliferation rate by 13.98%, 18.82%, and 17.94%, respectively. Tracheloside treatment (1, 5, and 10μg/mL) also increased cell healing activity by 38.14%, 106.13%, and 72.83%, respectively, compared to the control group. Also in HaCaT cells, tracheloside treatment at 1, 5, and 10μg/mL led to 1.3-, 1.67-, and 2.73-fold increase in the phosphorylation of ERK1/2, respectively[4]. In Sprague-Dawley rats, diet supplementation with 0.2% or 0.02% tracheloside did not significantly affect PhIP (100mg/kg body weight)-induced mammary carcinogenesis[5].

tracheloside 参考文献

[1]Kitamura Y, Yamagishi M, et al. Lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats. Cancer Lett. 2003 Oct 28;200(2):133-9.

[2]Yoo HH, Park JH, Kwon SW. An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius. Biosci Biotechnol Biochem. 2006 Nov;70(11):2783-5. Epub 2006 Nov 7.

[3]Yoo, H.H., Park, J.H., Kwon, S.W. An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius. Biosci Biotechnol Biochem. 2006;70(11):2783-2785.

[4]Kim, J., Shin, Y.K., Kim, K.Y. Promotion of Keratinocyte Proliferation by Tracheloside through ERK1/2 Stimulation. Evid Based Complement Alternat Med. 2018;2018:4580627.

[5]Kitamura, Y., Yamagishi, M., Okazaki, K. et al. Lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats. Cancer Lett. 2003;200(2):133-139.

tracheloside 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.82mL

0.36mL

0.18mL

9.08mL

1.82mL

0.91mL

18.16mL

3.63mL

1.82mL

tracheloside 技术信息

CAS号33464-71-0
分子式C27H34O12
分子量 550.552
别名
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Store in freezer, under -20°C

溶解方案

DMSO: 105 mg/mL(190.72 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方
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