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tracheloside

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Chemical Structure| 33464-71-0 同义名 : -
CAS号 : 33464-71-0
货号 : A333342
分子式 : C27H34O12
纯度 : 97%
分子量 : 550.552
MDL号 : MFCD00870631
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(190.72 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Tracheloside is a lignan glycoside isolated from the seeds of Trachelospermum jasminoides with anti-estrogenic activity. It has been shown to decreased the activity of alkaline phosphatase in Ishiwaka cells with an IC50 value of 0.31μg/mL[3]. Treatment of HaCaT cells with tracheloside at 1, 5, and 10μg/mL increased cell proliferation rate by 13.98%, 18.82%, and 17.94%, respectively. Tracheloside treatment (1, 5, and 10μg/mL) also increased cell healing activity by 38.14%, 106.13%, and 72.83%, respectively, compared to the control group. Also in HaCaT cells, tracheloside treatment at 1, 5, and 10μg/mL led to 1.3-, 1.67-, and 2.73-fold increase in the phosphorylation of ERK1/2, respectively[4]. In Sprague-Dawley rats, diet supplementation with 0.2% or 0.02% tracheloside did not significantly affect PhIP (100mg/kg body weight)-induced mammary carcinogenesis[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.82mL

0.36mL

0.18mL

9.08mL

1.82mL

0.91mL

18.16mL

3.63mL

1.82mL
参考文献

[1]Kitamura Y, Yamagishi M, et al. Lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats. Cancer Lett. 2003 Oct 28;200(2):133-9.

[2]Yoo HH, Park JH, Kwon SW. An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius. Biosci Biotechnol Biochem. 2006 Nov;70(11):2783-5. Epub 2006 Nov 7.

[3]Yoo, H.H., Park, J.H., Kwon, S.W. An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius. Biosci Biotechnol Biochem. 2006;70(11):2783-2785.

[4]Kim, J., Shin, Y.K., Kim, K.Y. Promotion of Keratinocyte Proliferation by Tracheloside through ERK1/2 Stimulation. Evid Based Complement Alternat Med. 2018;2018:4580627.

[5]Kitamura, Y., Yamagishi, M., Okazaki, K. et al. Lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats. Cancer Lett. 2003;200(2):133-139.