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Ximelagatran {[allProObj[0].p_purity_real_show]}

货号:A734242 同义名: H 376/95;Exanta

Ximelagatran是一种口服活性凝血酶抑制剂,选择性和竞争性地抑制游离和凝块结合的凝血酶。该化合物具有抗凝血作用,药代动力学和药效学表现出可预测的剂量依赖性,适用于抗凝血治疗的研究。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Ximelagatran 化学结构 CAS号:192939-46-1
Ximelagatran 化学结构
CAS号:192939-46-1
Ximelagatran 3D分子结构
CAS号:192939-46-1
Ximelagatran 化学结构 CAS号:192939-46-1
Ximelagatran 3D分子结构 CAS号:192939-46-1
规格 价格 会员价 库存 数量
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Ximelagatran 纯度/质量文件 产品仅供科研

货号:A734242 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Thrombin 其他靶点 纯度
Dabigatran +++

Thrombin, IC50: 9.3 nM

98%
Dabigatran etexilate 98%
Argatroban 99%+
Heparin sodium salt ≥150 u/mg
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Ximelagatran 生物活性

描述 Ximelagatran is an orally active thrombin inhibitor that selectively and competitively inhibits free or clot-bound thrombin. Ximelagatran can be used as an anticoagulant with rapid onset of action, predictable, dose-dependent pharmacokinetic and pharmacodynamic properties[1][2].Ximelagatran is currently being used in the development of anticoagulants for the prevention and treatment of thromboembolism. Ximelagatran is rapidly absorbed and rapidly converted to its active form, Melagatran. Preliminary studies have demonstrated the efficacy and safety of Ximelagatran in the prevention of venous thromboembolism following total knee or total hip arthroplasty[3]. .

Ximelagatran 参考文献

[1]Colwell CW Jr, et al. Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement. A randomized, double-blind study. J Thromb Haemost. 2003 Oct;1(10):2119-30.

[2]Gao JH, et al. Effects of different anticoagulant drugs on the prevention of complications in patients after arthroplasty: A network meta-analysis. Medicine (Baltimore). 2017 Oct;96(40):e8059.

[3]Francis CW, et al. Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement. N Engl J Med. 2003 Oct 30;349(18):1703-12.

Ximelagatran 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.11mL

0.42mL

0.21mL

10.56mL

2.11mL

1.06mL

21.12mL

4.22mL

2.11mL

Ximelagatran 技术信息

CAS号192939-46-1
分子式C24H35N5O5
分子量 473.565
别名 H 376/95;Exanta;Exarta;H 376-95
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 250 mg/mL(527.91 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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