Vinburnine | (-)-Vincamone | Drug Metabolite | AmBeed-信号通路专用抑制剂

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Vinburnine {[allProObj[0].p_purity_real_show]}

货号：A276263 同义名： (-)-Vincamone;(-)-Eburnamonine

Vincamone 是vincamine和vinpocetine的代谢物，具有血管扩张作用。

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Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Vinburnine 化学结构
CAS号：4880-88-0

Vinburnine 3D分子结构
CAS号：4880-88-0

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Vinburnine 纯度/质量文件产品仅供科研

货号：A276263 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JACS Au, 2024. Ambeed. [ A148168 ]; • JMC, 2024. Ambeed. [ A187643 ]; • JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]; • Biomacromolecules, 2024. Ambeed. [ A110759 ]; • Biomacromolecules, 2024. Ambeed. [ A203543 ]; 更多 >

Vinburnine 生物活性

描述

(-)-Eburnamonine (Vincamone) is a vasodilator that also acts as a cerebral metabolic stimulant. Pretreatment with vincamine could reduce Aβ25-35 induced oxidative stress. Vincamine markedly inhibited cell apoptosis dose-dependently. More importantly, vincamine increased the PI3K/Akt and Bcl-2 family protein ratios on preincubation with cells for 2 h^[3]. Vincamine exerted protective effects on hearing via improving neurotrophin-dependent PI3K/Akt signaling pathway in spiral ganglion neurons (SGNs)^[4]. Vincamine protected HCECs (human corneal epithelial cells) from LPS induced cell viability reduction and ameliorated the inflammation. Vincamine exhibited a strong antioxidant activity, decreasing ROS levels and regulating the levels of SOD (superoxide dismutase), T-AOC (total antioxidant capacity) and MDA (malondialdehyde). Vincamine also exerted anti-inflammatory activities by decreasing IL-6, IL-8, IL-1β, TNF-α, TGF-β expression^[5].

Vinburnine 参考文献

[1]Vas A, Gulyas B. Eburnamine derivatives and the brain. Med Res Rev. 2005 Nov;25(6):737-57.

[2]Spagnoli A, Tognoni G. 'Cerebroactive' drugs. Clinical pharmacology and therapeutic role in cerebrovascular disorders. Drugs. 1983 Jul;26(1):44-69.

[3]Han J, Qu Q, Qiao J, Zhang J. Vincamine Alleviates Amyloid-β 25-35 Peptides-induced Cytotoxicity in PC12 Cells. Pharmacogn Mag. 2017 Jan-Mar;13(49):123-128

[4]Li Y, Zou Q, Zhang J. Vincamine exerts protective effect on spiral ganglion neurons in endolymphatic hydrops guinea pig models. Am J Transl Res. 2018 Nov 15;10(11):3650-3663

[5]Wu L, Ye M, Zhang J. Vincamine prevents lipopolysaccharide induced inflammation and oxidative stress via thioredoxin reductase activation in human corneal epithelial cells. Am J Transl Res. 2018 Jul 15;10(7):2195-2204

Vinburnine 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.40mL

0.68mL

0.34mL

16.98mL

3.40mL

1.70mL

33.97mL

6.79mL

3.40mL

Vinburnine 技术信息

CAS号	4880-88-0
分子式	C₁₉H₂₂N₂O
分子量	294.391

别名	(-)-Vincamone;(-)-Eburnamonine
运输	蓝冰

存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 7 mg/mL(23.78 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

摩尔计算器

计算溶液所需的质量，体积或浓度。 Ambeed 摩尔浓度计算器基于以下方程式：

浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)=质量 (g)

浓度

体积

分子量

质量

Vinburnine {[allProObj[0].p_purity_real_show]}

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Vinburnine {[allProObj[0].p_purity_real_show]}

Vinburnine 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Vinburnine 质控信息

Vinburnine 生物活性

Vinburnine 参考文献

Vinburnine 实验方案

Vinburnine 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

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Vinburnine 纯度/质量文件产品仅供科研