There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
(-)-Eburnamonine (Vincamone) is a vasodilator that also acts as a cerebral metabolic stimulant. Pretreatment with vincamine could reduce Aβ25-35 induced oxidative stress. Vincamine markedly inhibited cell apoptosis dose-dependently. More importantly, vincamine increased the PI3K/Akt and Bcl-2 family protein ratios on preincubation with cells for 2 h[3]. Vincamine exerted protective effects on hearing via improving neurotrophin-dependent PI3K/Akt signaling pathway in spiral ganglion neurons (SGNs)[4]. Vincamine protected HCECs (human corneal epithelial cells) from LPS induced cell viability reduction and ameliorated the inflammation. Vincamine exhibited a strong antioxidant activity, decreasing ROS levels and regulating the levels of SOD (superoxide dismutase), T-AOC (total antioxidant capacity) and MDA (malondialdehyde). Vincamine also exerted anti-inflammatory activities by decreasing IL-6, IL-8, IL-1β, TNF-α, TGF-β expression[5].
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HazMat Fee +
