产品说明书
Vinburnine
 |
同义名 : | (-)-Vincamone;(-)-Eburnamonine |
| CAS号 : | 4880-88-0 | |
| 货号 : | A276263 | |
| 分子式 : | C19H22N2O | |
| 纯度 : | 99%+ | |
| 分子量 : | 294.391 | |
| MDL号 : | MFCD00064309 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 7 mg/mL(23.78 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | (-)-Eburnamonine (Vincamone) is a vasodilator that also acts as a cerebral metabolic stimulant. Pretreatment with vincamine could reduce Aβ25-35 induced oxidative stress. Vincamine markedly inhibited cell apoptosis dose-dependently. More importantly, vincamine increased the PI3K/Akt and Bcl-2 family protein ratios on preincubation with cells for 2 h[3]. Vincamine exerted protective effects on hearing via improving neurotrophin-dependent PI3K/Akt signaling pathway in spiral ganglion neurons (SGNs)[4]. Vincamine protected HCECs (human corneal epithelial cells) from LPS induced cell viability reduction and ameliorated the inflammation. Vincamine exhibited a strong antioxidant activity, decreasing ROS levels and regulating the levels of SOD (superoxide dismutase), T-AOC (total antioxidant capacity) and MDA (malondialdehyde). Vincamine also exerted anti-inflammatory activities by decreasing IL-6, IL-8, IL-1β, TNF-α, TGF-β expression[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.40mL 0.68mL 0.34mL |
16.98mL 3.40mL 1.70mL |
33.97mL 6.79mL 3.40mL |
| 参考文献 |
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[1]Vas A, Gulyas B. Eburnamine derivatives and the brain. Med Res Rev. 2005 Nov;25(6):737-57. |