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尿酸 /Uric acid {[allProObj[0].p_purity_real_show]}

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Uric acid activates NFκB in a variety of cell culture models including proximal tubular cells. Uric acid suppresses 1-α hydroxylase mRNA and protein expression in dose dependent and time dependent manner.

Uric acid 化学结构 CAS号:69-93-2
Uric acid 化学结构
CAS号:69-93-2
Uric acid 3D分子结构
CAS号:69-93-2
Uric acid 化学结构 CAS号:69-93-2
Uric acid 3D分子结构 CAS号:69-93-2
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Uric acid 纯度/质量文件 产品仅供科研

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产品名称 Hydroxylase 其他靶点 纯度
Ro 61-8048 +++

KMO, Ki: 4.8 nM

KMO, IC50: 37 nM

99%+
DMOG 98%
Nepicastat HCl +++

Bovine dopamine-beta-hydroxylase, IC50: 8.5 nM

Human dopamine-beta-hydroxylase, IC50: 9 nM

98%
Telotristat etiprate 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Uric acid 生物活性

描述 Uric acid acts as a scavenger of oxygen radicals and is a crucial antioxidant that helps maintain blood pressure stability and manage oxidative stress. It effectively removes reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, thus preventing lipid peroxidation[1].[2].
体内研究

Uric acid, administered orally at a dose of 250 mg/kg, mitigates indomethacin-induced enteropathy[2].

Oral administration of uric acid decreased ROS accumulation in the ileum in a mouse model of indomethacin-induced enteropathy[2].

体外研究

In experimental settings, Uric acid at a concentration of 400 μM for 48 hours protects Caco-2 cells from lipid peroxidation induced by indomethacin[2].

Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA for 24 hours) significantly reduces ROS levels compared to cells treated with indomethacin alone. Additionally, cell viability is enhanced in Caco-2 cells treated with both Indomethacin and Uric acid compared to those treated with only indomethacin. This indicates that Uric acid provides a protective effect against indomethacin-induced changes in intestinal cells through its antioxidant properties[2].

Uric acid 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00664144 Hyperuricemia Phase 2 Terminated(due to poor enrollm... 展开 >>ent) 收起 << - Belgium ... 展开 >> Sanofi-Aventis Administrative Office Diegem, Belgium France Sanofi- Aventis Administrative Office Paris, France Germany Sanofi-Aventis Administrative Office Berlin, Germany Italy Sanofi-Aventis Administrative Office Milan, Italy 收起 <<
NCT00477789 Chronic Heart Failure Phase 4 Completed - Italy ... 展开 >> Division of Cardiology, University Hospital of Verona Verona, Italy, 37129 收起 <<
NCT00290992 Nutritional and Metabolic Dise... 展开 >>ases 收起 << Phase 2 Completed - Japan ... 展开 >> Sanofi-Aventis Tokyo, Japan 收起 <<

Uric acid 参考文献

[1]Wang Q, et al. Recent Progress on Uric Acid Detection: A Review. Crit Rev Anal Chem. 2020;50(4):359-375.

[2]Yasutake Y, et al. Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity. J Gastroenterol Hepatol. 2017 Nov;32(11):1839-1845.

Uric acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.95mL

1.19mL

0.59mL

29.74mL

5.95mL

2.97mL

59.48mL

11.90mL

5.95mL

Uric acid 技术信息

CAS号69-93-2
分子式C5H4N4O3
分子量 168.11
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度

H2O: 6 mg/mL(35.69 mM),配合低频超声,并调节pH至10

1M NaOH: 8 mg/mL(47.59 mM),配合低频超声,水浴加热至45℃,并调节pH至12

动物实验配方
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