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/ 整合素 / Tirofiban hydrochloride monohydrate

盐酸替罗非班水合物 /Tirofiban hydrochloride monohydrate {[allProObj[0].p_purity_real_show]}

货号：A662355 同义名： 盐酸替罗非班 一水合物 / L700462 hydrochloride monohydrate;MK383 hydrochloride monohydrate

Tirofiban HCl H2O is a non-peptide reversible antagonist of the platelet integrin glycoprotein (GP) IIb/IIIa receptor used as an antiplatelet drug.

Tirofiban hydrochloride monohydrate 化学结构 CAS号：150915-40-5
Tirofiban hydrochloride monohydrate 化学结构
CAS号：150915-40-5
Tirofiban hydrochloride monohydrate 3D分子结构
CAS号：150915-40-5
Tirofiban hydrochloride monohydrate 化学结构 CAS号：150915-40-5
Tirofiban hydrochloride monohydrate 3D分子结构 CAS号：150915-40-5
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Tirofiban hydrochloride monohydrate 纯度/质量文件 产品仅供科研

货号：A662355 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Integrin ↓ 其他靶点 纯度
Tirofiban ✔ 99%+
ATN-161 ✔ 98%
RGD ✔ 98%
A-205804 ++

ICAM-1, IC50: 25 nM

E-selectin, IC50: 20 nM

 		98%
SB-273005 ++++

αvβ5 receptor, IC50: 0.3 nM

αvβ3 receptor, IC50: 1.2 nM

 		98+%
Lifitegrast ✔ 97%
Cilengitide TFA +++

αvβ5 receptor, IC50: 79 nM

αvβ3 receptor, IC50: 4.1 nM

 		99%+
Cyclo(-RGDfK) TFA ✔ 99%+
Cyclo(RGDyK) trifluoroacetate ++

αVβ3 integrin, IC50: 20 nM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Tirofiban hydrochloride monohydrate 生物活性

描述 The binding of glycoprotein (GP) IIb/IIIa receptor to fibrinogen is a prerequisite in platelet activation and aggregation. Tirofiban Hydrochloride Monohydrate is the hydrochloride monohydrate form of Tirofiban. Tirofiban is a potent GPIIb/IIIa antagonist. It inhibited the aggregation of in vitro human gel-filtered platelets induced by ADP, collagen, gamma-thrombin, and U46619 with IC50 values ranging from 12 nM to 31 nM. It also displayed inhibitory activity against human PRP platelet aggregation induced by ADP, collagen, gamma-thrombin, U46619, epinephrine, and arachidonic acid with IC50 values ranging from 31 nM to 66 nM. Tirofiban inhibited the platelet aggregation in human, rhesus monkey, and dog whole blood with IC50 values of 81, 140, and 353 nM, respectively. The intravenous administration of tirofiban (1 mg/kg) in dogs significantly inhibited ex vivo ADP-induced platelet aggregation in platelet-rich plasma (PRP) and the prolongation of template bleeding time. Continuous infusions of tirofiban (0.1-10 µg/kg/min) inhibited ex vivo platelet aggregation in PRP induced by ADP and collagen in a dose-dependent manner. Moreover, the combined treatment with tirofiban (1µg/kg/min, i.v., 120min) and ticlopidine (20 mg/kg/day, p.o., 4 days) in dogs did not change the pharmacokinetic profile of tirofiban nor the platelet count[3].

Tirofiban hydrochloride monohydrate 动物研究

Dose Rat: 1 mg/kg - 20 mg/kg[3] (i.v.) Dog: 0.12 mg/kg - 3.6 mg/kg[3] (i.v.)
Administration i.v.

Tirofiban hydrochloride monohydrate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01087723 Acute Coronary Syndrome Phase 3 Completed - -
NCT01087723 - Completed - -
NCT01103440 Stable Angina Phase 2 Completed - United States, New York ... 展开 >> Mount Sinai Medical Center New York, New York, United States, 10029 收起 <<

Tirofiban hydrochloride monohydrate 参考文献

[1]van 't Hof AW, Valgimigli M. Defining the role of platelet glycoprotein receptor inhibitors in STEMI: focus on tirofiban. Drugs. 2009;69(1):85-100.

[2]Winter JP, Juergens CP. The role of tirofiban in the management of coronary artery disease. Cardiovasc Hematol Disord Drug Targets. 2008 Jun;8(2):138-46.

[3]Tirofiban (Aggrastat®)

Tirofiban hydrochloride monohydrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.02mL

0.40mL

0.20mL

10.10mL

2.02mL

1.01mL

20.20mL

4.04mL

2.02mL

Tirofiban hydrochloride monohydrate 技术信息

CAS号150915-40-5
分子式C22H39ClN2O6S
分子量 495.073
别名 盐酸替罗非班 一水合物 ;L700462 hydrochloride monohydrate;MK383 hydrochloride monohydrate;Tirofiban (hydrochloride hydrate);MK-383 Hydrochloride;Tirofiban Hydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 105 mg/mL(212.09 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

PO 0.5% CMC-Na 31 mg/mL suspension

Tags: Tirofiban hydrochloride monohydrate | L700462 hydrochloride monohydrate;MK383 hydrochloride monohydrate;Tirofiban (hydrochloride hydrate);MK-383 Hydrochloride;Tirofiban Hydrochloride | 盐酸替罗非班 一水合物 | Integrin | AmBeed-信号通路专用抑制剂 | Tirofiban hydrochloride monohydrate 纯度/质量文件 | Tirofiban hydrochloride monohydrate 亚型比较 | Tirofiban hydrochloride monohydrate 生物活性 | Tirofiban hydrochloride monohydrate 动物研究 | Tirofiban hydrochloride monohydrate 临床数据 | Tirofiban hydrochloride monohydrate 参考文献 | Tirofiban hydrochloride monohydrate 实验方案 | Tirofiban hydrochloride monohydrate 技术信息

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