The binding of glycoprotein (GP) IIb/IIIa receptor to fibrinogen is a prerequisite in platelet activation and aggregation. Tirofiban is a potent GPIIb/IIIa antagonist. It inhibited the aggregation of in vitro human gel-filtered platelets induced by ADP, collagen, gamma-thrombin, and U46619 with IC50 values ranging from 12 nM to 31 nM. It also displayed inhibitory activity against human PRP platelet aggregation induced by ADP, collagen, gamma-thrombin, U46619, epinephrine, and arachidonic acid with IC50 values ranging from 31 nM to 66 nM. Tirofiban inhibited the platelet aggregation in human, rhesus monkey, and dog whole blood with IC50 values of 81, 140, and 353 nM, respectively. The intravenous administration of tirofiban (1 mg/kg) in dogs significantly inhibited ex vivo ADP-induced platelet aggregation in platelet-rich plasma (PRP) and the prolongation of template bleeding time. Continuous infusions of tirofiban (0.1-10 µg/kg/min) inhibited ex vivo platelet aggregation in PRP induced by ADP and collagen in a dose-dependent manner. Moreover, the combined treatment with tirofiban (1µg/kg/min, i.v., 120min) and ticlopidine (20 mg/kg/day, p.o., 4 days) in dogs did not change the pharmacokinetic profile of tirofiban nor the platelet count[3].
Non ST Elevation Myocardial In... 展开 >>farction 收起 <<
Phase 4
Completed
-
United States, New York
... 展开 >>
Albert Einstein College of Medicine
New York, New York, United States
Poland
First Department of Cardiac Surgery, Medical University of Silesia
Katowice, Slaskie, Poland, 40-635
Center for Cardiovascular Research and Development, American Heart of Poland
Katowice, Poland
Department of Internal Medicine and Clinical Pharmacology
Katowice, Poland
First Department of Cardiology, Medical University of Silesia
Katowice, Poland
Division of Molecular Biology and Clinical Genetics, Jagiellonian University Medical College
Krakow, Poland 收起 <<
Saudi Arabia
... 展开 >> Prince Sultan Cardiac Center
Recruiting
Riyadh, Saudi Arabia
Contact: Hussein S Alamri, MD amriheart@hotmail.com
Principal Investigator: Antonio Calafiore
Principal Investigator: Hussein S Alamri, MD
Principal Investigator: Abdulrahman M almoghairi, MD 收起 <<
Israel
... 展开 >> Cardiovascular Division, The Baruch Padeh Medical Center, Poriya,
Recruiting
Tiberias, Israel, 15208
Magen David ,
Recruiting
Tiberias, Israel
Contact: Sergay Krablikov, Dr 收起 <<
Korea, Republic of
... 展开 >>
Pusan National University Yangsan Hospital
Recruiting
Yangsan, Kyeongsangnamdo, Korea, Republic of, 626-770
Contact: June Hong Kim, MD, PhD +82-10-8231-7171 junehongk@gmail.com
Contact: Dongcheul Han, MD +82-10-2992-6270 usdoc12@gmail.com
Principal Investigator: June Hong Kim, MD,PhD
Sub-Investigator: Dongcheul Han, MD 收起 <<
Italy
... 展开 >> Divisione Di Cardiologia, Ospedale Maggiore
Bologna, BO, Italy, 40100
Laboratorio Di Emodinamica, Istituto Di Cardiologia, Azienda Ospedaliera S.Orsola Malpighi
Bologna, BO, Italy, 40138
Azienda Ospedaliera Universitaria Policlinico
Modena, MO, Italy, 41100
Divisione Di Cardiologia, Ospedale S.Maria Nuova
Reggio Emilia, RE, Italy, 42100
Divisione Di Cardiologia, Ospedale Per Gli Infermi
Rimini, RN, Italy, 47900
Divisione Di Cardiologia Ii, Ospedale Policlinico Le Molinette
Torino, TO, Italy, 10100 收起 <<
United States, Florida
... 展开 >>
Osceola Regional Medical Center
Completed
Kissimmee, Florida, United States, 34741
Northside Hospital
Completed
Saint Petersburg, Florida, United States, 33709
United States, Georgia
Emory University Hospital Midtown
Completed
Atlanta, Georgia, United States, 30308
Emory University Hospital
Completed
Atlanta, Georgia, United States, 30322
North Georgia Heart Center
Completed
Gainesville, Georgia, United States, 30501
Redmond Regional Medical Center
Recruiting
Rome, Georgia, United States, 30165
Principal Investigator: Hector R Picon, MD
Archbold Medical Center
Completed
Thomasville, Georgia, United States, 31792
United States, New York
Lenox Hill Hospital
Completed
New York, New York, United States, 10075
United States, Oklahoma
University of Oklahoma Health Sciences Center
Recruiting
Oklahoma City, Oklahoma, United States, 73104
Principal Investigator: Mazen Abu-Fadel, MD
United States, Pennsylvania
Doylestown Hospital
Completed
Doylestown, Pennsylvania, United States, 18901
Penn Presbyterian Medical Center
Completed
Philadelphia, Pennsylvania, United States, 19104
United States, Tennessee
Centennial Heart
Recruiting
Nashville, Tennessee, United States, 37203
Principal Investigator: Brian K Jefferson, MD
United States, Virginia
Chippenham Hospital
Recruiting
Richmond, Virginia, United States, 23225
Principal Investigator: Michael L Arcarese, MD 收起 <<
France
... 展开 >> Group Hospitalier Pitié-Salpetrière
Not yet recruiting
Paris, France, 75013
Contact: Jean-Philippe Collet, Prof jean-philippe.collet@aphp.fr
Italy
University of Ferrara
Not yet recruiting
Ferrara, Italy, 44124
Contact: Gianluca Campo, Prof cmpglc@unife.it
University of Naples Federico II
Recruiting
Naples, Italy, 80131
Contact: Giovanni Esposito, Prof espogiov@unina.it
University of Sassari
Not yet recruiting
Sassari, Italy, 07100
Contact: Guido Parodi, Prof parodiguido@gmail.com
Principal Investigator: Pierfranco Terrosu, MD
Switzerland
Bern University Hospital
Recruiting
Bern, Switzerland, 3010
Contact: Marco Valgimigli, Prof +41 316329653 marco.valgimigli@insel.ch
Contact: Giuseppe Gargiulo, MD +41 316327205 giuseppe.gargiulo@insel.ch 收起 <<
China, An Hui
... 展开 >> Suzhou Municipal Hoapital
Recruiting
Suzhou, An Hui, China
Contact: Zhengfei Ma, MD
China, Beijing
Xuanwu Hospital, Capital Medical University
Recruiting
Beijing, Beijing, China, 100053
Contact: Xunming Ji
Principal Investigator: Xunming Ji
China, Henan
The Central Hospital of Luohe City
Recruiting
Luohe, Henan, China
Contact: Shengming Huang, MD hsm912@126.com
China, Sichuan
Luzhou People's Hospital
Recruiting
Luzhou, Sichuan, China
Contact: Li Zhou, MD
China
Xiangtan Central Hospital
Recruiting
Xiangtan, China
Contact: Yong Liang
The Fifth Affiliated Hospital of Zhengzhou University
Recruiting
Zhengzhou, China
Contact: Lijun Wang
The First Affiliated Hospital of Zhengzhou University
Recruiting
Zhengzhou, China
Contact: Yajun Lian 收起 <<
United States, Virginia
... 展开 >>
Inova Health Care System
Recruiting
Falls Church, Virginia, United States, 22042
Contact: Kevin Bliden, BS, MBA 703-776-7702 kevin.bliden@inova.org 收起 <<
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