TTNPB is an agonist of RAR and can inhibit binding of [3H]tRA with RARα (IC50 = 5.1 nM), RARβ (IC50 = 4.5 nM), and RARγ (IC50 = 9.3 nM).
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
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Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
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Accessible (Haz class 3, 4, 5 or 8), International
TTNPB (Ro 13-7410) (GMP) refers to TTNPB produced following GMP guidelines. GMP small molecules serve as appropriate auxiliary reagents for cell therapy manufacture. TTNPB is a highly potent retinoic acid receptor (RAR) agonist.
体外研究
TTNPB inhibits binding of [3H]tRA with IC50s of 3.8 nM, 4 nM, and 4.5 nM for human RARα, β, and γ, respectively. TTNPB competes for [3H]tRA binding to CRABPI with IC50s of 1800 nM[1].
The combination of TTNPB (Ro 13-7410) (GMP) (100 nM) and Laduviglusib can induce chondrogenic markers in hiPSCs and form hyaline cartilaginous tissues in vivo[2].
TTNPB (Arotinoid Acid) 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
CV-1 cells
Function assay
Binding affinity against retinoic Acid gamma receptors co-transfected into CV-1 cells, EC50=0.002 Μm
8308867
HEK293 cells
Function assay
Agonist activity at human RARalpha expressed in HEK293 cells by luciferase reporter gene assay, EC50=0.18 nM
25305688
HeLa cells
Function assay
Agonist activity at human RARalpha expressed in human HeLa cells assessed as relative luminescence units at >=10 uM by luciferase assay relative to control
18951029
HL60 cells
Cytotoxicity assay
In vitro cytotoxicity against HL60 cells, IC50=46 μM
Binding affinity against retinoic Acid gamma receptors co-transfected into CV-1 cells, EC50=0.002 Μm
8308867
HEK293 cells
Function assay
Agonist activity at human RARalpha expressed in HEK293 cells by luciferase reporter gene assay, EC50=0.18 nM
25305688
HeLa cells
Function assay
Agonist activity at human RARalpha expressed in human HeLa cells assessed as relative luminescence units at >=10 uM by luciferase assay relative to control
18951029
HL60 cells
Cytotoxicity assay
In vitro cytotoxicity against HL60 cells, IC50=46 μM
搜索
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