Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
囊泡 肿瘤
/
PI3K/Akt/mTOR
干细胞 帕金森与阿尔茨海默症 肿瘤发展和微环境演变 Wnt Hedgehog (Hh)
/ GSK-3 / TDZD-8

TDZD-8 {[allProObj[0].p_purity_real_show]}

货号：A251413 同义名： NP 01139;GSK-3β Inhibitor I

TDZD-8, the derivative of thiadiazolidinone, is a selective inhibitor of GSK-3. It inhibits GSK-3β with IC50 of 2 μM.

TDZD-8 化学结构 CAS号：327036-89-5
TDZD-8 化学结构
CAS号：327036-89-5
TDZD-8 3D分子结构
CAS号：327036-89-5
TDZD-8 化学结构 CAS号：327036-89-5
TDZD-8 3D分子结构 CAS号：327036-89-5
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

TDZD-8 纯度/质量文件 产品仅供科研

货号：A251413 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Cell, 2024, 101755. Ambeed. [ A399663 ]
• EMBO J., 2024. Ambeed. [ A295334 ]
• JMC, 2024, 67(20): 18265-18289. Ambeed. [ A538667 , A341145 , A117430 , A172297 ]
• JMC, 2024. Ambeed. [ A210558 , A1518164 ]
• Cell Death Discov., 2024, 10, 436. Ambeed. [ A384235 ]
更多 >
产品名称 GSK-3 ↓ GSK-3α ↓ GSK-3β ↓ 其他靶点 纯度
AZD2858 +

GSK-3, IC50: 68 nM

 		98+%
Bikinin ✔ 99%+
GSK 3 Inhibitor IX ++++

GSK-3, IC50: 5 nM

 		99%+
AZD1080 +++

GSK-3α, IC50: 6.9 nM

 		++

GSK-3β, IC50: 31 nM

 		99%+
BIO-acetoxime +++

GSK-3α, IC50: 10 nM

 		+++

GSK-3β, IC50: 10 nM

 		95%
SB-216763 ++

GSK-3α, IC50: 34.3 nM

 		++

GSK-3β, IC50: ~34.3 nM

 		98%
SB 415286 +

GSK-3α, IC50: 78 nM

 		+

GSK-3β, IC50: ~78 nM

 		99%+
CHIR-98014 ++++

GSK-3α, IC50: 0.65 nM

 		++++

GSK-3β, IC50: 0.58 nM

 		98%
LY2090314 ++++

GSK-3α, IC50: 1.5 nM

 		++++

GSK-3β, IC50: 0.9 nM

 		99%+
CHIR 99021 +++

GSK-3α, IC50: 10 nM

 		++++

GSK-3β, IC50: 6.7 nM

 		99%+
TDZD-8 +

GSK-3β, IC50: 2 μM

 		99%+
Indirubin +

GSK-3β, IC50: 0.6 μM

 		98%
IM-12 ++

GSK-3β, IC50: 53 nM

 		98%
TWS119 ++

GSK-3β, IC50: 30 nM

 		98%
1-Azakenpaullone +++

GSK-3β, IC50: 18 nM

 		99%+
AR-A014418 ++

GSK-3β, Ki: 38 nM

 		99%+
Tideglusib +

GSK-3β, IC50: 60 nM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

TDZD-8 生物活性

靶点

  • GSK-3β

    GSK-3β, IC50:2 μM
描述 TDZD-8 is the first non-ATP competitive inhibitor of GSK-3β with IC50 value of 2μM. Pretreatment with TDZD-8 at 10μM for 1h showed neuroprotection against 6-OHDA-induced damage, shown by reduced cell death and apoptosis, in both SH-SY5Y cells and cultured CGNs. Intrahippocampal delivery of TDZD-8 blocked dephosphorylation and activation of GSK3β in db/db mice. This inhibition of GSK3β prevented accumulation of pS202Tau and hyperphosphorylation of pS396/404Tau in db/db mice. It also reduced somatodendritic tau phosphorylation in db/db mice. The normalization of spatial recognition memory in db/db mice and block of deficits in novel object study could also be observed. Recent study found that TDZD-8 showed inhibition effect on 2019-nCoV.
作用机制 TDZD-8 is a non-ATP competitive GSK-3β inhibitor.

TDZD-8 参考文献

[1]Guzman ML, Li X, et al. Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8). Blood. 2007 Dec 15;110(13):4436-44.

[2]Martinez A, Alonso M, et al. First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J Med Chem. 2002 Mar 14;45(6):1292-9.

TDZD-8 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.50mL

0.90mL

0.45mL

22.50mL

4.50mL

2.25mL

44.99mL

9.00mL

4.50mL

TDZD-8 技术信息

CAS号327036-89-5
分子式C10H10N2O2S
分子量 222.264
别名 NP 01139;GSK-3β Inhibitor I;TDZD 8. GSK3 Inhibitor I
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C
溶解度

DMSO: 105 mg/mL(472.41 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: TDZD-8 | 327036-89-5 | GSK-3β Inhibitor I | NP 01139 | TDZD8 | TDZD 8 | NP01139 | NP 01139 | NP-01139 | GSK-3 Inhibitor | PI3K/Akt/mTOR | Stem Cell/Wnt | GSK-3 | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | TDZD-8 纯度/质量文件 | TDZD-8 亚型比较 | TDZD-8 生物活性 | TDZD-8 参考文献 | TDZD-8 实验方案 | TDZD-8 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z