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Bikinin {[allProObj[0].p_purity_real_show]}

货号:A176791 同义名: Abrasin

Bikinin acts as an ATP-competitive inhibitor of arabidopsis GSK-3 and effective activator of brassinosteroid (BR) signaling.

Bikinin 化学结构 CAS号:188011-69-0
Bikinin 化学结构
CAS号:188011-69-0
Bikinin 3D分子结构
CAS号:188011-69-0
Bikinin 化学结构 CAS号:188011-69-0
Bikinin 3D分子结构 CAS号:188011-69-0
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Bikinin 纯度/质量文件 产品仅供科研

货号:A176791 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 GSK-3 GSK-3α GSK-3β 其他靶点 纯度
AZD2858 +

GSK-3, IC50: 68 nM

98+%
Bikinin 99%+
GSK 3 Inhibitor IX ++++

GSK-3, IC50: 5 nM

99%+
AZD1080 +++

GSK-3α, IC50: 6.9 nM

++

GSK-3β, IC50: 31 nM

99%+
BIO-acetoxime +++

GSK-3α, IC50: 10 nM

+++

GSK-3β, IC50: 10 nM

95%
SB-216763 ++

GSK-3α, IC50: 34.3 nM

++

GSK-3β, IC50: ~34.3 nM

98%
SB 415286 +

GSK-3α, IC50: 78 nM

+

GSK-3β, IC50: ~78 nM

99%+
CHIR-98014 ++++

GSK-3α, IC50: 0.65 nM

++++

GSK-3β, IC50: 0.58 nM

98%
LY2090314 ++++

GSK-3α, IC50: 1.5 nM

++++

GSK-3β, IC50: 0.9 nM

99%+
CHIR 99021 +++

GSK-3α, IC50: 10 nM

++++

GSK-3β, IC50: 6.7 nM

99%+
TDZD-8 +

GSK-3β, IC50: 2 μM

99%+
Indirubin +

GSK-3β, IC50: 0.6 μM

98%
IM-12 ++

GSK-3β, IC50: 53 nM

98%
TWS119 ++

GSK-3β, IC50: 30 nM

98%
1-Azakenpaullone +++

GSK-3β, IC50: 18 nM

99%+
AR-A014418 ++

GSK-3β, Ki: 38 nM

99%+
Tideglusib +

GSK-3β, IC50: 60 nM

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Bikinin 生物活性

靶点
  • GSK-3

描述 Bikinin is a non-steroidal, ATP-competitive inhibitor of plant GSK-3(Glycogen synthase kinase 3)/Shaggy-like kinases and activates BR (brassinosteroids) signaling. Bikinin reduces transcript levels of NbRBOHB and BR-induced NbRBOHB expression in TRV:00, TRV:NbDWARF, TRV:NbBRI1, TRV:NbBSK1, TRV:NbBAK1, TRV:NbBIK1 and TRV:NbBSU1 plants. Bikinin largely inhibits BR-increased ROS accumulation[3]. Bikinin directly binds the GSK3 BIN2 and acts as an ATP competitor. Furthermore, bikinin inhibits the activity of six other Arabidopsis GSK3s. Genome-wide transcript analyses demonstrate that simultaneous inhibition of seven GSK3s is sufficient to activate BR responses[4]. Bikinin, a GSK3 kinase inhibitor, inhibited the SnRK2.3 kinase activity and its T180 phosphorylation in vivo[5].

Bikinin 参考文献

[1]Cai Z, Liu J, et al. GSK3-like kinases positively modulate abscisic acid signaling through phosphorylating subgroup III SnRK2s in Arabidopsis. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9651-6.

[2]De Rybel B, Audenaert D, et al. Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling. Chem Biol. 2009 Jun 26;16(6):594-604.

[3]Deng XG, Zhu T, Peng XJ, Xi DH, Guo H, Yin Y, Zhang DW, Lin HH. Role of brassinosteroid signaling in modulating Tobacco mosaic virus resistance in Nicotiana benthamiana. Sci Rep. 2016 Feb 3;6:20579

[4]De Rybel B, Audenaert D, Vert G, Rozhon W, Mayerhofer J, Peelman F, Coutuer S, Denayer T, Jansen L, Nguyen L, Vanhoutte I, Beemster GT, Vleminckx K, Jonak C, Chory J, Inzé D, Russinova E, Beeckman T. Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling. Chem Biol. 2009 Jun 26;16(6):594-604

[5]Cai Z, Liu J, Wang H, Yang C, Chen Y, Li Y, Pan S, Dong R, Tang G, Barajas-Lopez Jde D, Fujii H, Wang X. GSK3-like kinases positively modulate abscisic acid signaling through phosphorylating subgroup III SnRK2s in Arabidopsis. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9651-6

Bikinin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.66mL

0.73mL

0.37mL

18.31mL

3.66mL

1.83mL

36.62mL

7.32mL

3.66mL

Bikinin 技术信息

CAS号188011-69-0
分子式C9H9BrN2O3
分子量 273.083
别名 Abrasin
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 40 mg/mL(146.48 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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