BIO-acetoxime is an inhibitor of GSK3α and GSK3β with IC50 of 10 nM.
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HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International
In mammals, different genes encode two closely related glycogen synthase kinase-3 (GSK-3) enzymes, GSK-3α and GSK-3β which function in Wnt signal-transducing pathways, insulin action, apoptosis and circadian rhythm. BIO-acetoxime is a potent and selective GSK-3 inhibitor, with IC50s of 10 nM for both GSK-3α and GSK-3β. It also shows weak effect on CDK5/p35, CDK2/cyclin A, and CDK1/cyclin B with IC50s of 2.4, 4.3 and 63 μM, respectively[3]. Treatment of OC3 cells with BIO-acetoxime (5 or 10 μM) prevented HSV-1-induced cell death. In addition, BIO-acetoxime alleviated HSV-1-induced apoptosis. In oral epithelial cells, BIO-acetoxime inhibited HSV-1 propagation in a dose-dependent manner[4]. In a rat limbic seizure model, the pilocarpine-induced seizures are indeed significantly attenuated after i.p. injection of 0.5 mg/kg BIO-acetoxime[5].
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