Streptozotocin | Streptozocin;NSC-85998;streptozotocin.SZN;SZC;NRRL 2697;AI3-50821;NCI-C03167;NSC 37917;Estreptozocin;STZ;U 9889 | 链脲佐菌素 | Diabete Model | DNA Alkylator/Crosslinker

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链脲菌素 /Streptozotocin {[allProObj[0].p_purity_real_show]}

货号：A667625 同义名： 链脲佐菌素 / Streptozocin;NSC-85998

Streptozotocin (Streptozocin) 是一种广泛用于实验动物中诱导糖尿病的抗生素。Streptozotocin 通过葡萄糖转运蛋白 (GLUT2) 进入 β 细胞并导致 DNA 烷基化，从而引起 β 细胞凋亡。

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Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Streptozotocin 化学结构
CAS号：18883-66-4

Streptozotocin 3D分子结构
CAS号：18883-66-4

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Streptozotocin 纯度/质量文件产品仅供科研

货号：A667625 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

Streptozotocin 生物活性

描述

The alkylation of DNA by carcinogens such as the alkyl nitrosoureas is a critical event in the induction of tumors by these compounds. Streptozotocin, an antibiotic widely used for induction of diabetes in experimental animals and for the treatment of pancreatic neoplasms, was shown to be a potent methylating agent reacting with DNA in vitro to form methylated purines. Rats received streptozotocin (21 mg/kg; 2 mCi/kg) by i.v. injection for 2 hours before death. The liver was alkylated to the greatest extent followed by the kidney. In both of these organs, the degree of methylation was significantly greater than that observed with N-methyl-N-nitrosourea. While methylation of brain DNA by streptozotocin was very low, suggesting that the compound does not penetrate well into the nervous system^[3]. Male C57BL/6 mice were under inhalation anesthesia injected via the penile vein with streptozocin (180 mg/kg). Treated mice showed elevated blood glucose levels 48 h after drug injection and reduced body weight significantly compared with control group. Streptozocin also significantly attenuated the numbers of splenocytes and white blood cells (WBC) at 96 h post injection^[4].

Streptozotocin 动物研究

Animal study

糖尿病
动物：C57BL/6 小鼠，雌雄皆可，10周龄。
给药：200 mg/kg ，腹腔注射，单次高剂量

Streptozotocin 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01362530	Chemotherapy Induced Nausea an... 展开 >>d Vomiting 收起 <<	Phase 3	Completed	-	-
NCT01362530	-		Completed	-	-
NCT00003543	Colorectal Cancer	Phase 1	Completed	-	United States, New York ... 展开 >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 收起 <<

Streptozotocin 参考文献

[1]Diab RA, Fares M, et al. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies. Immunol Lett. 2015 Feb;163(2):193-8.

[2]Bennett RA, Pegg AE. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul;41(7):2786-90.

[3]Bennett RA, Pegg AE. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul;41(7):2786-90. PMID: 6454479.

[4]Diab RA, Fares M, Abedi-Valugerdi M, Kumagai-Braesch M, Holgersson J, Hassan M. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies. Immunol Lett. 2015 Feb;163(2):193-8. doi: 10.1016/j.imlet.2014.12.006. Epub 2015 Jan 5. PMID: 25573197.

Streptozotocin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.77mL

0.75mL

0.38mL

18.85mL

3.77mL

1.89mL

37.70mL

7.54mL

3.77mL

Streptozotocin 技术信息

CAS号	18883-66-4
分子式	C₈H₁₅N₃O₇
分子量	265.22

别名	链脲佐菌素 ;Streptozocin;NSC-85998;streptozotocin. US brand name: Zanosar.;SZN;SZC;NRRL 2697;AI3-50821;NCI-C03167;NSC 37917;Estreptozocin;STZ;U 9889
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 250 mg/mL(942.61 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 110 mg/mL(414.75 mM)

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01362530	Chemotherapy Induced Nausea an... 展开 >>d Vomiting 收起 <<	Phase 3	Completed	-	-
NCT01362530	-		Completed	-	-
NCT00003543	Colorectal Cancer	Phase 1	Completed	-	United States, New York ... 展开 >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 收起 <<
NCT01709123	Diabetes Mellitus, Type 1	Not Applicable	Unknown	September 2013	United States, Louisiana ... 展开 >> Louisiana State University Health Sciences Center in Shreveport Recruiting Shreveport, Louisiana, United States, 71130 Contact: Sushil K Jain, Ph.D. 318-675-6086 sjain@lsuhsc.edu Sub-Investigator: Robert McVie, M.D. Sub-Investigator: Tommie Stapleton, RN, CCRC Sub-Investigator: Cynthia Brewer, RN Sub-Investigator: John Rowell, RN, MSN Sub-Investigator: Henry R McKnight, RPH Sub-Investigator: Pat F Bass, M.D. Sub-Investigator: Shikha Mane, M.D. Sub-Investigator: David Micinski, BS Sub-Investigator: Neslihan Gungor, M.D. 收起 <<
NCT03758014	GBM	Phase 2 Phase 3	Recruiting	April 30, 2021	China, Beijing ... 展开 >> Beijing Tiantan Hospital, Capital Medical University Recruiting Beijing, Beijing, China Contact: Wenbin Li 收起 <<
NCT00448136	Neoplasms	Phase 2	Completed	-	France ... 展开 >> Angers, France, 49933 Bordeaux, France, 33075 Boulogne Billancourt, France, 92104 Caen, France, 14033 Chambray Les Tours, France, 37171 Clichy, France, 92118 Creteil, France, 94010 Dijon, France, 21079 Lille, France, 59020 Lyon, France, 69437 Marseille, France, 13273 Marseille, France, 13285 Marseille, France, 13385 Montpellier, France, 34298 Nantes, France, 44093 Nice, France, 06189 Paris, France, 75571 Paris, France, 75651 Paris, France, 75908 Paris, France, 75970 Poitiers, France, 86021 Reims, France, 51092 Rouen, France, 76031 Saint Brieuc, France, 22015 Strasbourg, France, 67091 Toulouse, France, 31059 Villejuif, France, 94805 收起 <<
NCT03217097	Neuroendocrine Tumors	Phase 4	Not yet recruiting	October 2021	France ... 展开 >> Hôpital Sud - CHU Amiens Not yet recruiting Amiens, France, 80054 Contact: Vincent HAUTEFEUILLE, MD Principal Investigator: Vincent HAUTEFEUILLE, MD CHU d'Angers Not yet recruiting Angers, France, 49933 Contact: Sandrine LABOUREAU, MD Principal Investigator: Sandrine LABOUREAU, MD Hôpital Beaujon - APHP Not yet recruiting Clichy, France, 92118 Contact: Olivia HENTIC, MD Principal Investigator: Olivia HENTIC, MD Hôpital François Mitterrand - CHU Dijon Bourgogne Not yet recruiting Dijon, France, 21000 Contact: Côme LEPAGE, MD Principal Investigator: Côme LEPAGE, MD Hôpital André Michalon - CHU Grenoble Alpes Not yet recruiting La Tronche, France, 38700 Contact: Victoire GRANGER, MD Principal Investigator: Victoire GRANGER, MD Centre Oscar Lambret Not yet recruiting Lille, France, 59020 Contact: Eric DANSIN, MD Principal Investigator: Eric DANSIN, MD Hôpital Claude Hurriet - CHRU Lille Not yet recruiting Lille, France, 59037 Contact: Christine DO CAO, MD Principal Investigator: Christine DO CAO, MD Hôpital Edouard Herriot - Hospices Civils de Lyon Not yet recruiting Lyon, France, 69003 Contact: Thomas WALTER, MD Principal Investigator: Catherine LOMBARD BOHAS, MD Sub-Investigator: Thomas WALTER, MD Hôpital Privé Jean Mermoz Not yet recruiting Lyon, France, 69008 Contact: Jérôme DESRAMES, MD Principal Investigator: Jérôme DESRAMES, MD Centre Léon Bérard Not yet recruiting Lyon, France, 69373 Contact: Matthieu SARABI, MD Principal Investigator: Matthieu SARABI, MD Institut Paoli Calmettes Not yet recruiting Marseille, France, 13009 Contact: Patricia NICCOLI, MD Principal Investigator: Patricia NICCOLI, MD Hôpital Saint Eloi - CHU Montpellier Not yet recruiting Montpellier, France, 34090 Contact: Eric ASSENAT, MD Principal Investigator: Eric ASSENAT, MD Hôpital Saint Louis - APHP Not yet recruiting Paris, France, 75010 Contact: Thomas APARICIO, MD Principal Investigator: Thomas APARICIO, MD Hôpital Cochin - APHP Not yet recruiting Paris, France, 75014 Contact: Romain CORIAT, MD Principal Investigator: Romain CORIAT, MD CH Annecy Genevois Not yet recruiting Pringy, France, 74374 Contact: Mathieu BACONNIER, MD Principal Investigator: Mathieu BACONNIER, MD Hôpital Robert Debré - CHU Reims Not yet recruiting Reims, France, 51092 Contact: Guillaume CADIOT, MD Principal Investigator: Guillaume CADIOT, MD Hôpital Nord - CHU Saint Etienne Not yet recruiting Saint-Priest-en-Jarez, France, 42270 Contact: Nicolas WILLIET, MD Principal Investigator: Nicolas WILLIET, MD Institut de Cancérologie de la Loire Not yet recruiting Saint-Priest-en-Jarez, France, 42270 Contact: Léa SABAN-ROCHE, MD Principal Investigator: Léa SABAN-ROCHE, MD Hôpital Rangueil - CHU Toulouse Not yet recruiting Toulouse, France, 31059 Contact: Rosine GUIMBAUD, MD Principal Investigator: Rosine GUIMBAUD, MD Hôpital Trousseau - CHU Tours Not yet recruiting Tours, France, 37044 Contact: Thierry LECOMTE, MD Principal Investigator: Thierry LECOMTE, MD Institut Gustave Roussy Not yet recruiting Villejuif, France, 94805 Contact: Eric BAUDIN, MD Principal Investigator: Eric BAUDIN, MD 收起 <<
NCT00633763	-		Completed	-	United States, California ... 展开 >> University of California Irvine Medical Center Orange, California, United States, 92868 收起 <<
NCT02246127	Neuroendocrine Tumors	Phase 3	Recruiting	June 2020	-
NCT00094497	Carcinoma, Adrenal Cortical	Phase 3	Completed	-	United States, Maryland ... 展开 >> National Cancer Institute - Center for Cancer Research Bethesda, Maryland, United States United States, Michigan University of Michigan, Department of Internal Medicine Ann Arbor, Michigan, United States, 48109 Australia Royal Adelaide Hospital Adelaide, Australia, SA 5000 Austria University of Graz Graz, Austria, 8036 France Clinique Marc Linquette Lille, France Centre Leon Berard Lyon, France Hospital de Marseille la timone Marseille, France, 13385 Cochin Hospital Paris, France, 75679 Hospital Bordeaux haut leveque Pessac, France, 33600 Institut Gustave Roussy Villejuif, France, 94805 Germany Charité-University, Dept. of Endocrinology; Campus Benjamin Franklin Berlin, Germany Charité-Universitätsmedizin Berlin - Campus Mitte Berlin, Germany Dept. of Medicine III Dresden, Germany University of Duesseldorf, Dept. of Endocrrinology Duesseldorf, Germany, 40001 Zentrum für Innere Medizin - Endokrinologie des Universitätsklinikum Essen Essen, Germany Endokrinologie Medizinische Hochschule Hannover Hannover, Germany Otto-von-Guericke University; Dept. of Endocrinology Magdeburg, Germany, 39120 Dept of Medicine I Mainz, Germany University of Munich, Dept. of Internal Medicine (Innenstadt) Munich, Germany, 80336 University of Wuerzburg - Dept. of Medicine Wuerzburg, Germany, 97080 Italy University of Turin, Dept of Internal Medicine Orbassano, Italy, 10043 Clinica Endocrinologica, Università di Padova, Azienda Ospedaliera di Padova Padova, Italy Netherlands Vrije Universiteit Medisch Centrum Amsterdam, Netherlands, 1007 Academisch Medisch Centrum; Dept. of Endocrinology Amsterdam, Netherlands, 1105 AZ Maxima Medisch Centrum; Dept. of Internal Medicine Eindhoven, Netherlands, 5631 BM University Hospital Groningen; Dept. of Internal Medine Groningen, Netherlands, 9700 Leiden University Medical Center Leiden, Netherlands Sweden Department of Oncology, Sahlgrenska University Hospital Gothenburg, Sweden Department of Oncology, Linköping University Hospital Linköping, Sweden Department of Medicine, The Jubileum Institute, Lund University Lund, Sweden Dept of Surgery, Karolinska Hospital, Stockholm Stockholm, Sweden Uppsala University Hospital - Dept of Medical Sciences Uppsala, Sweden, 751 85 收起 <<
NCT00094497	-		Completed	-	-
NCT00001165	Islet Cell Adenoma ... 展开 >> Neoplasm Metastasis Zollinger Ellison Syndrome 收起 <<	Phase 2	Completed	-	United States, Maryland ... 展开 >> National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Bethesda, Maryland, United States, 20892 收起 <<
NCT03351296	Pancreatic Cancer	Phase 2	Not yet recruiting	June 2023	France ... 展开 >> Gustave Roussy Not yet recruiting Villejuif, Val De Marne, France, 94805 Contact: Michel Ducreux, MD, PhD 0142116017 ext +33 michel.ducreux@gustaveroussy.fr Contact: Dune Lemettre 0142116643 ext +33 dune.lemettre@gustaveroussy.fr 收起 <<
NCT00602082	Gastrointestinal Carcinoid Tum... 展开 >>or Islet Cell Tumor 收起 <<	Phase 2	Completed	-	United Kingdom ... 展开 >> Basildon University Hospital Basildon, England, United Kingdom, SS16 5NL Addenbrooke's Hospital Cambridge, England, United Kingdom, CB2 2QQ Cookridge Hospital Leeds, England, United Kingdom, LS16 6QB Leicester Royal Infirmary Leicester, England, United Kingdom, LE1 5WW Aintree University Hospital Liverpool, England, United Kingdom, L9 7AL UCL Cancer Institute London, England, United Kingdom, NW3 2QG St. Thomas' Hospital London, England, United Kingdom, SE1 7EH Mid Kent Oncology Centre at Maidstone Hospital Maidstone, England, United Kingdom, ME16 9QQ Christie Hospital Manchester, England, United Kingdom, M20 4BX Clatterbridge Centre for Oncology Merseyside, England, United Kingdom, CH63 4JY Northern Centre for Cancer Treatment at Newcastle General Hospital Newcastle-Upon-Tyne, England, United Kingdom, NE4 6BE Oxford Radcliffe Hospital Oxford, England, United Kingdom, 0X3 9DU Royal Marsden - Surrey Sutton, England, United Kingdom, SM2 5PT Southend University Hospital NHS Foundation Trust Westcliff-On-Sea, England, United Kingdom, SS0 0RY Edinburgh Cancer Centre at Western General Hospital Edinburgh, Scotland, United Kingdom, EH4 2XU Beatson West of Scotland Cancer Centre Glasgow, Scotland, United Kingdom, G12 0YN Velindre Cancer Center at Velindre Hospital Cardiff, Wales, United Kingdom, CF14 2TL 收起 <<
NCT00609765	Pancreatic Cancer	Phase 2	Terminated(Development of new ... 展开 >>chemotherapy standard of care for treatment rendered the trial obsolete.) 收起 <<	-	United States, Florida ... 展开 >> H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 收起 <<
NCT00609765	-		Terminated(Development of new ... 展开 >>chemotherapy standard of care for treatment rendered the trial obsolete.) 收起 <<	-	-
NCT00448136	-		Completed	-	-
NCT00004688	Anaplastic Astrocytoma ... 展开 >> Anaplastic Oligodendroglioma Mixed Gliomas Glioblastoma Multiforme Recurrent Brain Tumor 收起 <<	Phase 2	Completed	-	-
NCT03612232	Adrenocortical Carcinoma	Phase 2	Not yet recruiting	June 2022	Germany ... 展开 >> University Hospital Würzburg Not yet recruiting Würzburg, Germany, 97080 Contact: Matthias Kroiss, MD, PhD +4993120139740 Kroiss_M@ukw.de Contact: Martin Fassnacht, MD +4993120139200 Fassnacht_M@ukw.de 收起 <<

链脲菌素 /Streptozotocin {[allProObj[0].p_purity_real_show]}

Streptozotocin 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Streptozotocin 质控信息

Streptozotocin 生物活性

Streptozotocin 动物研究

Streptozotocin 临床研究

Streptozotocin 参考文献

Streptozotocin 实验方案

Streptozotocin 技术信息

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链脲菌素 /Streptozotocin {[allProObj[0].p_purity_real_show]}

Streptozotocin 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Streptozotocin 质控信息

Streptozotocin 生物活性

Streptozotocin 动物研究

Streptozotocin 临床研究

Streptozotocin 参考文献

Streptozotocin 实验方案

Streptozotocin 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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