产品说明书
Streptozotocin
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同义名 : | 链脲佐菌素 ;Streptozocin;NSC-85998;streptozotocin. US brand name: Zanosar.;SZN;SZC;NRRL 2697;AI3-50821;NCI-C03167;NSC 37917;Estreptozocin;STZ;U 9889 |
| CAS号 : | 18883-66-4 | |
| 货号 : | A667625 | |
| 分子式 : | C8H15N3O7 | |
| 纯度 : | 98% ≥85% α-anomer basis | |
| 分子量 : | 265.22 | |
| MDL号 : | MFCD00006607 | |
| 存储条件： |
粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(942.61 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 110 mg/mL(414.75 mM) |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | The alkylation of DNA by carcinogens such as the alkyl nitrosoureas is a critical event in the induction of tumors by these compounds. Streptozotocin, an antibiotic widely used for induction of diabetes in experimental animals and for the treatment of pancreatic neoplasms, was shown to be a potent methylating agent reacting with DNA in vitro to form methylated purines. Rats received streptozotocin (21 mg/kg; 2 mCi/kg) by i.v. injection for 2 hours before death. The liver was alkylated to the greatest extent followed by the kidney. In both of these organs, the degree of methylation was significantly greater than that observed with N-methyl-N-nitrosourea. While methylation of brain DNA by streptozotocin was very low, suggesting that the compound does not penetrate well into the nervous system[3]. Male C57BL/6 mice were under inhalation anesthesia injected via the penile vein with streptozocin (180 mg/kg). Treated mice showed elevated blood glucose levels 48 h after drug injection and reduced body weight significantly compared with control group. Streptozocin also significantly attenuated the numbers of splenocytes and white blood cells (WBC) at 96 h post injection[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01362530 | Chemotherapy Induced Nausea an... 展开 >>d Vomiting 收起 << | Phase 3 | Completed | - | - |
| NCT01362530 | - | Completed | - | - | |
| NCT00003543 | Colorectal Cancer | Phase 1 | Completed | - | United States, New York ... 展开 >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.77mL 0.75mL 0.38mL |
18.85mL 3.77mL 1.89mL |
37.70mL 7.54mL 3.77mL |
| 参考文献 |
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