Streptozotocin (Streptozocin) 是一种广泛用于实验动物中诱导糖尿病的抗生素。Streptozotocin 通过葡萄糖转运蛋白 (GLUT2) 进入 β 细胞并导致 DNA 烷基化，从而引起 β 细胞凋亡。

Colchicine是一种微管蛋白抑制剂和微管破坏剂，IC50 为 3 nM，还能作为 α3 甘氨酸受体 (GlyRs) 的竞争性拮抗剂。

Okadaic acid is extracted from black sponges of the genus Halichondria. Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A and PP3 inhibitor with IC50s of 10-15 nM, 0.5 nM and 4 nM, respectively.