StemRegenin 1
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货号：A108671
同义名：
SR1
StemRege nin 1 是一种有效的芳香烃受体 (AhR ) 拮抗剂，IC50 为 127 nM。
StemRegenin 1 化学结构
StemRegenin 1 3D分子结构
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StemRegenin 1 纯度/质量文件 产品仅供科研
货号：A108671
标准纯度：
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StemRegenin 1 质控信息
StemRegenin 1
++
Aryl hydrocarbon receptor (AhR), IC50: 127 nM
99%+
CH-223191
+++
99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
StemRegenin 1 生物活性
靶点
描述
The aryl hydrocarbon receptor (AHR) is a ligand-inducible transcription factor that is best known because it mediates the actions of polycyclic and halogenated aromatic hydrocarbon environmental toxicants such as 3-methylcholanthrene and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin [3] 50 of 127 nM. Culture of hematopoietic stem cells (HSCs) with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice, resulting from antagonizing the AHR [4]
StemRegenin 1 参考文献
[1] Gori JL, Chandrasekaran D, et al. Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells. Blood. 2012 Sep 27;120(13):e35-44.
[2] Boitano AE, Wang J, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010 Sep 10;329(5997):1345-8.
[3] Song J, Clagett-Dame M, Peterson RE, Hahn ME, Westler WM, Sicinski RR, DeLuca HF. A ligand for the aryl hydrocarbon receptor isolated from lung. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14694-9. doi: 10.1073/pnas.232562899. Epub 2002 Oct 30. PMID: 12409613; PMCID: PMC137481.
[4] Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010 Sep 10;329(5997):1345-8. doi: 10.1126/science.1191536. Epub 2010 Aug 5. Erratum in: Science. 2011 May 6;332(6030):664. PMID: 20688981; PMCID: PMC3033342.
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StemRegenin 1 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.33mL
0.47mL
0.23mL
11.64mL
2.33mL
1.16mL
23.28mL
4.66mL
2.33mL
StemRegenin 1 技术信息
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