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Stattic

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Chemical Structure| 19983-44-9 同义名 : STAT3 Inhibitor V
CAS号 : 19983-44-9
货号 : A109795
分子式 : C8H5NO4S
纯度 : 98%
分子量 : 211.195
MDL号 : MFCD00173799
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(236.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

5% DMSO+40% PEG 300+5% Tween 80+50% water 10 mg/mL

生物活性
靶点

  • STAT3

    STAT3, IC50:5.1 μM
描述 Stattic acts as a potent inhibitor of STAT3 and impedes STAT3 phosphorylation at Y705 and S727 [1]. Stattic hampers the binding of a high-affinity phosphopeptide for the SH2 domain of STAT3 [2]. Stattic improves renal function in Alport syndrome (AS) mice [3].
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
A431 2 μM Growth Inhibition Assay 2 h blocks EGF-reversed decreases in cell viability 25720435
A431 2 μM Growth Inhibition Assay 2 h increases in apoptosis induced by shikonin 25720435
C13* 0-10 μM Apoptosis Assay 24/48 h induces apoptosis in a dose and time dependent manner 23962558
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.73mL

0.95mL

0.47mL

23.67mL

4.73mL

2.37mL

47.35mL

9.47mL

4.73mL
参考文献

[1]Lin L, et al. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. Int J Oncol. 2016 Oct 12.

[2]John S McMurray, et al. A new small-molecule Stat3 inhibitor. Chem Biol. 2006 Nov;13(11):1123-4.

[3]Tsubasa Yokota, et al. STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model. Nephrol Dial Transplant. 2018 Feb 1;33(2):214-223.