Sepantronium bromide | Apoptosis | Survivin | AmBeed-信号通路专用抑制剂

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Sepantronium bromide {[allProObj[0].p_purity_real_show]}

货号：A307284

YM155 is an inhibitor of survivin with IC50 of 0.54 nM.

Sepantronium bromide 化学结构
CAS号：781661-94-7

Sepantronium bromide 3D分子结构
CAS号：781661-94-7

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Sepantronium bromide 纯度/质量文件产品仅供科研

货号：A307284 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell, 2024, 101755. Ambeed. [ A399663 ]; • EMBO J., 2024. Ambeed. [ A295334 ]; • JMC, 2024, 67(20): 18265-18289. Ambeed. [ A538667 , A341145 , A117430 , A172297 ]; • JMC, 2024. Ambeed. [ A210558 , A1518164 ]; • Cell Death Discov., 2024, 10, 436. Ambeed. [ A384235 ]; 更多 >

生存素亚型比较

产品名称	Survivin ↓ ↑	其他靶点	纯度
Sepantronium bromide	+++ Survivin, IC50: 0.54 nM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Sepantronium bromide 生物活性

靶点

Survivin

Survivin, IC50:0.54 nM

描述

Survivin is a member of the inhibitor of apoptosis (IAP) protein family and has been implicated in both cell survival and regulation of mitosis in cancer. YM155 is a potent survivin inhibitor with IC₅₀ value of 0.54 nM for survivin promoter activity^[2]. YM155 suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human hormone-refractory prostate cancer (HRPC) cell lines at 10 nM, but showed little effect on expression levels of other IAP- or Bcl-2-related proteins up to 100 nM. In a s.c. xenografted PC-3 tumor model in mice, 3-day continuous infusions of YM155 at 3 to 10 mg/kg induced massive tumor regression accompanied by suppression of intratumoral surviving and no significant decreases in body weight were observed^[2]. Glioma cell lines responded in a dose and time-dependent manner to YM-155 with reduction of cell numbers. U373, LN18, LNZ428, T98G, LN229, and LNZ308 cells exhibited an IC₅₀ of ~ 10-75 nM, while A172 cells were resistant to YM-155 with IC₅₀ ~ 250 nM^[3]. Exposure of U373 and LN18 (YM-155 sensitive) glioma cells to 25 nM of YM-155 for 24 h caused a marked loss of mitochondrial membrane potential compared with the control group^[3]. Primary effusion lymphoma-patient-derived xenograft mice were treated with YM-155 (5 mg/kg) from days 2-22. The volume of ascites was significantly less in YM155-treated mice than in control mice on day 22 (0.75 mL [median, range 0-2.56 mL] vs. 3.96 mL [median, range 0.7-5.29 mL], p < 0.01)^[4].

Sepantronium bromide 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
A2780cis	0-100 nM	Function Assay	24 h	induces Survivin downregulation	24262875
A2780cis	5-100 nM	Apoptosis Assay	24/48 h	increases apoptosis in a concentration-dependent manner	24262875
A2780p	0-100 nM	Function Assay	24 h	induces Survivin downregulation	24262875
A2780p	5-100 nM	Apoptosis Assay	24/48 h	increases apoptosis in a concentration-dependent manner	24262875

Sepantronium bromide 参考文献

[2]Nakahara T, Kita A, Yamanaka K, Mori M, Amino N, Takeuchi M, Tominaga F, Hatakeyama S, Kinoyama I, Matsuhisa A, Kudoh M, Sasamata M. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res. 2007 Sep 1;67(17):8014-21. doi: 10.1158/0008-5472.CAN-07-1343. Erratum in: Cancer Res. 2012 Aug 1;72(15):3886. Mori, Masamichi [added]; Amino, Nobuaki [added]; Hatakeyama, Shinji [added];Minematsu, Tsuyoshi [removed]; Shirasuna, Kenna[removed]. PMID: 17804712.

[3]Jane EP, Premkumar DR, DiDomenico JD, Hu B, Cheng SY, Pollack IF. YM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context. Mol Cancer Ther. 2013 Mar;12(3):326-38. doi: 10.1158/1535-7163.MCT-12-0901. Epub 2013 Jan 16. PMID: 23325792; PMCID: PMC3596447.

[4]Kojima Y, Hayakawa F, Morishita T, Sugimoto K, Minamikawa Y, Iwase M, Yamamoto H, Hirano D, Imoto N, Shimada K, Okada S, Kiyoi H. YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma. Pharmacol Res. 2017 Jun;120:242-251. doi: 10.1016/j.phrs.2017.04.006. Epub 2017 Apr 8. PMID: 28396094.

Sepantronium bromide 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.26mL

0.45mL

0.23mL

11.28mL

2.26mL

1.13mL

22.56mL

4.51mL

2.26mL

Sepantronium bromide 技术信息

CAS号	781661-94-7
分子式	C₂₀H₁₉BrN₄O₃
分子量	443.294

别名
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

溶解度

DMSO: 50 mg/mL(112.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 50 mg/mL(112.79 mM)，配合低频超声助溶

动物实验配方

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

A2780cis	0-100 nM	Function Assay	24 h	induces Survivin downregulation	24262875
A2780cis	5-100 nM	Apoptosis Assay	24/48 h	increases apoptosis in a concentration-dependent manner	24262875
A2780p	0-100 nM	Function Assay	24 h	induces Survivin downregulation	24262875
A2780p	5-100 nM	Apoptosis Assay	24/48 h	increases apoptosis in a concentration-dependent manner	24262875
A375		Growth Inhibition Assay		GI50=6.3 nM	21737502
ACC-2	0-100 nM	Growth Inhibition Assay	24 h	inhibits cell growth in a dose-dependent manner	24370995
ACC-2	0-20 nM	Apoptosis Assay	24 h	induces apoptosis in a dose-dependent manner	24370995
ACC-2	0-20 nM	Function Assay	24 h	increases the conversion of LC3I to LC3II	24370995
AGS	10/20 nM	Growth Inhibition Assay	48 h	inhibits cell growth in a dose-dependent manner	25635055
AML-193		Growth Inhibition Assay	72 h	IC50=0.462 ± 0.060 μM	25659731
AML-193	0–1 μM	Function Assay	72 h	induces downregulation of Survivin	25659731
BFTC905	0-1000 nM	Growth Inhibition Assay	48 h	IC50=20 nM, inhibits cell growth in a dose-dependent manner	24297644
BFTC905	20 nM	Apoptosis Assay	48 h	induces apoptosis	24297644
BFTC905	20 nM	Function Assay	48 h	decreases the expression of LC3B-II	24297644
BFTC909	0-1000 nM	Growth Inhibition Assay	48 h	IC50=20 nM, inhibits cell growth in a dose-dependent manner	24297644
BxPC-3	0.01-1000 nM	Growth Inhibition Assay	48 h	IC50=30.26 nM	22723871
BxPC-3	0-1000 nM	Function Assay	24 h	induces downregulation of XIAP and survivin expression	22723871
CMK		Growth Inhibition Assay	72 h	IC50=0.053 ± 0.009 μM	25659731
CMK	0–1 μM	Function Assay	72 h	induces downregulation of Survivin	25659731
DB	10 nM	Growth Inhibition Assay	24 h	inhibits cell proliferation	24486595
DB		Growth Inhibition Assay	48 h	GI50=3.5 nM	21237508
Eca109	1-50 nM	Function Assay	48 h	suppresses survivin expression in a dose dependent manner	25139395
Eca109	0-100 nM	Growth Inhibition Assay	24/48 h	decreases cell viability in a dose-dependent manner	25139395
HEK293	0.1-1000 nM	Growth Inhibition Assay		EC50=23.0 nM, inhibits cell growth in a dose-dependent manner	22961763
HEL		Growth Inhibition Assay	72 h	IC50=0.559 ± 0.038 μM	25659731
HG-1	0-500 nM	Growth Inhibition Assay	48 h	inhibits cell growth in a dose-dependent manner	25296978
HL-60		Growth Inhibition Assay	72 h	IC50=0.001 ± 0.0002 μM	25659731
HL-60		Growth Inhibition Assay	72 h	IC50=0.3 nM	23618862
HL-60	1 μM	Function Assay	6/12/24 h	inhibits the expression of survivin	23618862
HL-60	0.1/1 μM	Apoptosis Assay	8 h	induces apoptosis	23618862
INA-6	0-500 nM	Growth Inhibition Assay	48 h	inhibits cell growth in a dose-dependent manner	25296978
INA-6	0-50 nM	Apoptosis Assay	24 h	induces apoptosis	25296978
Kasumi-1		Growth Inhibition Assay	72 h	IC50=0.009 ± 0.0009 μM	25659731
Kasumi-1	0–1 μM	Function Assay	72 h	induces downregulation of Survivin	25659731
KATOIII	10/20 nM	Growth Inhibition Assay	48 h	inhibits cell growth in a dose-dependent manner	25635055
KMS-12-BM	0-500 nM	Growth Inhibition Assay	48 h	inhibits cell growth in a dose-dependent manner	25296978
L-363	0-500 nM	Growth Inhibition Assay	48 h	inhibits cell growth in a dose-dependent manner	25296978
M059J	0-50 nM	Growth Inhibition Assay	48 h	inhibits cell growth in a dose-dependent manner	22770110
M059J	30 nM	Apoptosis Assay	24 h	induces apoptosis	22770110
M059K	0-50 nM	Growth Inhibition Assay	48 h	inhibits cell growth in a dose-dependent manner	22770110
M059K	30 nM	Apoptosis Assay	24 h	induces apoptosis	22770110
M-07e		Growth Inhibition Assay	72 h	IC50=0.040 ± 0.013 μM	25659731
M-07e	0–1 μM	Function Assay	72 h	induces downregulation of Survivin	25659731
MCF7		Growth Inhibition Assay	72 h	IC50=13 ± 6 nM	25220225
MCF7-TamC3		Growth Inhibition Assay	72 h	IC50=6 ± 3 nM	25220225
MCF7-TamC6		Growth Inhibition Assay	72 h	IC50=6 ± 0.1 nM	25220225
MCF7-TamR6		Growth Inhibition Assay	72 h	IC50=8 ± 6 nM	25220225
MCF7-TamR7		Growth Inhibition Assay	72 h	IC50=8 ± 3 nM	25220225
MCF7-TamR8		Growth Inhibition Assay	72 h	IC50=15 ± 6 nM	25220225
MDA-MB-231		Growth Inhibition Assay	72 h	IC50=5 ± 1 nM	25220225
MDA-MB-468		Kinase Assay	72 h	IC50=0.11 ± 0.01 nM for DR4 expression	24866585
MDA-MB-468		Kinase Assay	72 h	IC50=0.07 ± 0.02 nM for DR5 expression	24866585
ME-1		Growth Inhibition Assay	72 h	IC50=0.684 ± 0.179 μM	25659731
MIAPaCa-2	0.01-1000 nM	Growth Inhibition Assay	48 h	IC50=29.36 nM	22723871
MIAPaCa-2	0-1000 nM	Function Assay	24 h	induces downregulation of XIAP and survivin expression	22723871
ML-2		Growth Inhibition Assay	72 h	IC50=0.009 ± 0.002 μM	25659731
MOLP-2	0-500 nM	Growth Inhibition Assay	48 h	inhibits cell growth in a dose-dependent manner	25296978
MOLP-8	0-500 nM	Growth Inhibition Assay	48 h	inhibits cell growth in a dose-dependent manner	25296978
MT-3		Kinase Assay	72 h	IC50=2.86 ± 0.54 nM for DR4 expression	24866585
MT-3		Kinase Assay	72 h	IC50=54.11 ± 4.32 nM for DR5 expression	24866585
MT-3 + NAC		Kinase Assay	72 h	IC50=56.2 ± 2.07 nM for DR5 expression	24866585
MT-3 + SB203580		Kinase Assay	72 h	IC50=38.41 ± 5.02 nM for DR5 expression	24866585
MUG-Chor	0-5 μM	Growth Inhibition Assay	24/48 h	IC50=7.05 nM for 48h	25640185
MV4-11		Growth Inhibition Assay	72 h	IC50=0.055 ± 0.028 μM	25659731
MV4-11	0–1 μM	Function Assay	72 h	induces downregulation of Survivin	25659731
NCI-H929	0-500 nM	Growth Inhibition Assay	48 h	inhibits cell growth in a dose-dependent manner	25296978
OCI/AML3		Growth Inhibition Assay	72 h	IC50=0.011 ± 0.002 μM	25659731
OPM-2	0-500 nM	Growth Inhibition Assay	48 h	inhibits cell growth in a dose-dependent manner	25296978
PANC-1	0.01-1000 nM	Growth Inhibition Assay	48 h	IC50=3.69 nM	22723871
PANC-1	0-1000 nM	Function Assay	24 h	induces downregulation of XIAP and survivin expression	22723871
Pfeiffer		Growth Inhibition Assay	48 h	GI50=3.9 nM	21237508
RD-ES	0.1-1000 nM	Growth Inhibition Assay		EC50=6.2 nM, inhibits cell growth in a dose-dependent manner	22961763
RPMI-7951		Growth Inhibition Assay		GI50=3.2 nM	21737502
SACC-83	5 nM	Function Assay	48 h	decreases nuclear expression of HIF-1α	25485635
SH-SY5Y	1/10/100 µM	Apoptosis Assay	72 h	induces apoptosis in a dose-dependent manner	24254560
SK-BR-3		Growth Inhibition Assay	72 h	IC50=7 ± 0.3 nM	25220225
SK-ES-1	0.1-1000 nM	Growth Inhibition Assay		EC50=2.8 nM, inhibits cell growth in a dose-dependent manner	22961763
SK-MEL-2		Growth Inhibition Assay		GI50=11 nM	21737502
SK-MEL-28		Growth Inhibition Assay		GI50=7.6 nM	21737502
SK-MEL-5		Growth Inhibition Assay		GI50=4.2 nM	21737502
SK-MM-2	0-500 nM	Growth Inhibition Assay	48 h	inhibits cell growth in a dose-dependent manner	25296978
Sk-NEP-1	1-10000 nM	Growth Inhibition Assay	24 h	IC50=100 nM	23267699
SK-NEP-1	50/100 nM	Apoptosis Assay	12/24 h	induces apoptosis	23267699
SU-DHL-5		Growth Inhibition Assay	48 h	GI50=0.23 nM	21237508
SU-DHL-8	10 nM	Growth Inhibition Assay	24 h	inhibits cell proliferation	24486595
SU-DHL-8		Growth Inhibition Assay	48 h	GI50=1.4 nM	21237508
SUM-159		Kinase Assay	72 h	IC50=1.72 ± 0.33 nM for DR4 expression	24866585
SUM-159		Kinase Assay	72 h	IC50=69.4 ± 4.23 nM for DR5 expression	24866585
T24	0-1000 nM	Growth Inhibition Assay	48 h	IC50=20 nM, inhibits cell growth in a dose-dependent manner	24297644
TC-32	0.1-1000 nM	Growth Inhibition Assay		EC50=3.0 nM, inhibits cell growth in a dose-dependent manner	22961763
TC-71	0.1-1000 nM	Growth Inhibition Assay		EC50=5.7 nM, inhibits cell growth in a dose-dependent manner	22961763
TE13	1-50 nM	Function Assay	48 h	suppresses survivin expression in a dose dependent manner	25139395
TE13	0-100 nM	Growth Inhibition Assay	24/48 h	decreases cell viability in a dose-dependent manner	25139395
THP-1		Growth Inhibition Assay	72 h	IC50=0.051 ± 0.013 μM	25659731
THP-1	1 μM	Apoptosis Assay	72 h	induces apoptosis	25659731
THP-1	0–1 μM	Function Assay	72 h	induces downregulation of Survivin	25659731
TSGH8301	0-1000 nM	Growth Inhibition Assay	48 h	IC50=20 nM, inhibits cell growth in a dose-dependent manner	24297644
U-266	0-500 nM	Growth Inhibition Assay	48 h	inhibits cell growth in a dose-dependent manner	25296978
U-266	0-50 nM	Apoptosis Assay	24 h	induces apoptosis	25296978
U937		Growth Inhibition Assay	72 h	IC50=0.8 nM	23618862
U937	1 μM	Function Assay	6/12/24 h	inhibits the expression of survivin	23618862
U-CH1	0-5 μM	Growth Inhibition Assay	24/48 h	IC50=9.03 nM for 48h	25640185
WSU-DLCL2	10 nM	Growth Inhibition Assay	24 h	inhibits cell proliferation	24486595
WSU-DLCL-2		Growth Inhibition Assay	48 h	GI50=1.4 nM	21237508

Sepantronium bromide {[allProObj[0].p_purity_real_show]}

Sepantronium bromide 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Sepantronium bromide 质控信息

Sepantronium bromide 生物活性

Sepantronium bromide 细胞研究

Sepantronium bromide 参考文献

Sepantronium bromide 实验方案

Sepantronium bromide 技术信息

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Sepantronium bromide 技术信息

最近浏览的产品

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确认信息

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