Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of μ-opioid receptor, with analgesic effect. Intrathecal SOG (sec-O-glucosylhamaudol) significantly increased PWT (paw withdrawal thresholds) in a dose-dependent manner. Maximum effects were achieved at a dose of 300 μg at 60 min after SOG administration, and the maximal possible effect was 85.35% at that time. The medial effective dose of intrathecal SOG was 191.3 μg. The antinociceptive effects of SOG (300 μg) were significantly reverted until 60 min by naloxone. The protein levels of MOR were decreased by administration of SOG. Intrathecal SOG showed a significant antinociceptive effect on the postoperative pain model and reverted by naloxone[3]. Intrathecal SOG showed a significant reduction of the flinching responses at both phases in a dose-dependent manner. Significant effects were showed from the dose of 30 µg and maximum effects were achieved at a dose of 100 µg in both phases. The antinociceptive effects of SOG (100 µg) were significantly reverted at both phases of the formalin test by naloxone[4]. Imperatorin and sec-O-glucosylhamaudol can ameliorate As2O3-induced (arsenic trioxide) cytotoxicity and apoptosis in H9c2 cells, the mechanisms probably related to antioxidation[5].
搜索
