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Sec-O-Glucosylhamaudol

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Chemical Structure| 80681-44-3 同义名 : Hamaudol 3-glucoside
CAS号 : 80681-44-3
货号 : A310151
分子式 : C21H26O10
纯度 : 95%
分子量 : 438.425
MDL号 : MFCD11042255
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(239.49 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of μ-opioid receptor, with analgesic effect. Intrathecal SOG (sec-O-glucosylhamaudol) significantly increased PWT (paw withdrawal thresholds) in a dose-dependent manner. Maximum effects were achieved at a dose of 300 μg at 60 min after SOG administration, and the maximal possible effect was 85.35% at that time. The medial effective dose of intrathecal SOG was 191.3 μg. The antinociceptive effects of SOG (300 μg) were significantly reverted until 60 min by naloxone. The protein levels of MOR were decreased by administration of SOG. Intrathecal SOG showed a significant antinociceptive effect on the postoperative pain model and reverted by naloxone[3]. Intrathecal SOG showed a significant reduction of the flinching responses at both phases in a dose-dependent manner. Significant effects were showed from the dose of 30 µg and maximum effects were achieved at a dose of 100 µg in both phases. The antinociceptive effects of SOG (100 µg) were significantly reverted at both phases of the formalin test by naloxone[4]. Imperatorin and sec-O-glucosylhamaudol can ameliorate As2O3-induced (arsenic trioxide) cytotoxicity and apoptosis in H9c2 cells, the mechanisms probably related to antioxidation[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.28mL

0.46mL

0.23mL

11.40mL

2.28mL

1.14mL

22.81mL

4.56mL

2.28mL
参考文献

[1]Wen C, Lin C, et al. Determination of sec-O-glucosylhamaudol in rat plasma by gradient elution liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jan 1;944:35-8.

[2]Gui Y, Tsao R, et al. Preparative separation of chromones in plant extract of Saposhnikovia divaricata by high-performance counter-current chromatography. J Sep Sci. 2011 Mar;34(5):520-6.

[3]Koh GH, Song H, Kim SH, et al. Effect of sec-O-glucosylhamaudol on mechanical allodynia in a rat model of postoperative pain. Korean J Pain. 2019;32(2):87-96

[4]Kim SH, Jong HS, Yoon MH, Oh SH, Jung KT. Antinociceptive effect of intrathecal sec-O-glucosylhamaudol on the formalin-induced pain in rats. Korean J Pain. 2017;30(2):98-103

[5]Hu L, Sun J, Li H, et al. Differential mechanistic investigation of protective effects from imperatorin and sec-O-glucosylhamaudol against arsenic trioxide-induced cytotoxicity in vitro. Toxicol In Vitro. 2016;37:97-105